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Middle To Late Pleistocene Paleoenvironmental Reconstructions From Lake El'gygytgyn, Arctic Russia, Mary Helen Habicht
Middle To Late Pleistocene Paleoenvironmental Reconstructions From Lake El'gygytgyn, Arctic Russia, Mary Helen Habicht
Doctoral Dissertations
Climate change is a major issue challenging the world today. Our global society faces rising temperatures, variable weather patterns, and rising sea level among other associated issues. Our action (or inaction) to address current changes will have serious ramifications for life on our planet in the coming centuries and millennia. In order to provide context for these present and future changes, we can utilize the paleo record to understand the natural variability of Earth’s climate system. One region of the world is changing more rapidly than the global average. Over recent decades, the Arctic has experienced warmer temperatures, reduced sea …
Enhanced Mass Spectrometric Analysis Of Peptides And Proteins Using Polymeric Reverse Micelles, Mahalia Adelina Corazon Paningbatan Serrano
Enhanced Mass Spectrometric Analysis Of Peptides And Proteins Using Polymeric Reverse Micelles, Mahalia Adelina Corazon Paningbatan Serrano
Doctoral Dissertations
Mass spectrometry (MS) has become a key and indispensable tool in the identification, characterization, and quantitative analysis of proteins owing to its universality, sensitivity, specificity, and its capability for multiplexed detection. Because biological samples containing these protein analytes are almost always complex systems, various techniques are employed in conjunction with MS to fully harness its analytical potential and enhance its detection capabilities. This dissertation explores the use of amphiphilic polymeric reverse micelles in enriching proteins and peptides from complex biological mixtures and in enhancing their mass spectrometric analysis. Fundamental studies that elucidate the molecular basis for the observed MS signal …