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Rechecking The Centrality-Lethality Rule In The Scope Of Protein Subcellular Localization Interaction Networks, Xiaoqing Peng, Jianxin Wang, Jun Wang, Fangxiang Wu, Yi Pan

Computer Science Faculty Publications

Essential proteins are indispensable for living organisms to maintain life activities and play important roles in the studies of pathology, synthetic biology, and drug design. Therefore, besides experiment methods, many computational methods are proposed to identify essential proteins. Based on the centrality-lethality rule, various centrality methods are employed to predict essential proteins in a Protein-protein Interaction Network (PIN). However, neglecting the temporal and spatial features of protein-protein interactions, the centrality scores calculated by centrality methods are not effective enough for measuring the essentiality of proteins in a PIN. Moreover, many methods, which overfit with the features of essential proteins for …