Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Pancreas-Targeted Nir Fluorophores For Dual-Channel Image-Guided Abdominal Surgery, Hideyuki Wada, Hoon Hyun, Christina Vargas, Julien Gravier, Gwangli Park, Sylvain Gioux, John V. Frangioni, Maged Henary, Hak Soo Choi
Pancreas-Targeted Nir Fluorophores For Dual-Channel Image-Guided Abdominal Surgery, Hideyuki Wada, Hoon Hyun, Christina Vargas, Julien Gravier, Gwangli Park, Sylvain Gioux, John V. Frangioni, Maged Henary, Hak Soo Choi
Chemistry Faculty Publications
Objective: Pancreas-related complications are some of the most serious ones in abdominal surgery. The goal of this study was to develop and validate novel near-infrared (NIR) fluorophores that would enable real-time pancreas imaging to avoid the intraoperative pancreatic injury. Design: After initial screening of a large NIR fluorophore library, the performance of 3 selected pancreas-targeted 700 nm NIR fluorophores, T700-H, T700-F, and MB, were quantified in mice, rats, and pigs. Dose ranging using 25 and 100 nmol, and 2.5 μmol of T700-F, and its imaging kinetics over a 4 h period were tested in each species. Three different 800 nm …
Simultaneous Mapping Of Pan And Sentinel Lymph Nodes For Real-Time Image-Guided Surgery, Yoshitomo Ashitate, Hoon Hyun, Soon Hee Kim, Jeong Heon Lee, Maged Henary, John V. Frangioni, Hak Soo Choi
Simultaneous Mapping Of Pan And Sentinel Lymph Nodes For Real-Time Image-Guided Surgery, Yoshitomo Ashitate, Hoon Hyun, Soon Hee Kim, Jeong Heon Lee, Maged Henary, John V. Frangioni, Hak Soo Choi
Chemistry Faculty Publications
The resection of regional lymph nodes in the basin of a primary tumor is of paramount importance in surgical oncology. Although sentinel lymph node mapping is now the standard of care in breast cancer and melanoma, over 20% of patients require a completion lymphadenectomy. Yet, there is currently no technology available that can image all lymph nodes in the body in real time, or assess both the sentinel node and all nodes simultaneously. In this study, we report an optical fluorescence technology that is capable of simultaneous mapping of pan lymph nodes (PLNs) and sentinel lymph nodes (SLNs) in the …