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Competition; mass spectrometry; electrospray; minor groove binder; DNA; transcription factor; specificity
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May The Best Molecule Win: Competition Esi Mass Spectrometry, Sarah R. Laughlin, W. David Wilson
May The Best Molecule Win: Competition Esi Mass Spectrometry, Sarah R. Laughlin, W. David Wilson
Chemistry Faculty Publications
Electrospray ionization mass spectrometry has become invaluable in the characterization of macromolecular biological systems such as nucleic acids and proteins. Recent advances in the field of mass spectrometry and the soft conditions characteristic of electrospray ionization allow for the investigation of non-covalent interactions among large biomolecules and ligands. Modulation of genetic processes through the use of small molecule inhibitors with the DNA minor groove is gaining attention as a potential therapeutic approach. In this review, we discuss the development of a competition method using electrospray ionization mass spectrometry to probe the interactions of multiple DNA sequences with libraries of minor …