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Spectrophotometric And Spectrofluorimetric Studies On Azilsartan Medoxomil And Chlorthalidone To Be Utilized In Their Determination In Pharmaceuticals, Walid M. Ebeid, Ehab F. Elkady, Asmaa A. El-Zaher, Ramzia I. El-Bagary, Gabor Patonay

Chemistry Faculty Publications

The recently approved angiotensin II receptor blocker, azilsartan medoxomil (AZL), was determined spectrophotometrically and spectrofluorimetrically in its combination with chlorthalidone (CLT) in their combined dosage form. The UV-spectrophotometric technique depends on simultaneous measurement of the first derivative spectra for AZL and CLT at 286 and 257 nm, respectively, in methanol. The spectrofluorimetric technique depends on measurement of the fourth derivative of the synchronous spectra intensities of AZL in presence of CLT at 298 nm in methanol. The effects of different solvents on spectrophotometric and spectrofluorimetric responses were studied. For, the spectrofluorimetric study, the effect of pH and micelle-assisted fluorescence enhancement …