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Di-Cationic Arylimidamides Act Against Neospora Caninum Tachyzoites By Interference In Membrane Structure And Nucleolar Integrity And Are Active Against Challenge Infection In Mice, Michelle Schorer, Karim Debache, Fabienne Barna, Thierry Monney, David Boykin, Chad E. Stevens, Andrew Hemphill
Di-Cationic Arylimidamides Act Against Neospora Caninum Tachyzoites By Interference In Membrane Structure And Nucleolar Integrity And Are Active Against Challenge Infection In Mice, Michelle Schorer, Karim Debache, Fabienne Barna, Thierry Monney, David Boykin, Chad E. Stevens, Andrew Hemphill
Chemistry Faculty Publications
Neospora caninum is considered to be the main cause of bovine abortion in Europe and the USA, leading to considerable financial impact. Losses are caused directly by abortions or indirectly through breeding of calves with impaired viability. Due to the lack of effective chemotherapy against bovine neosporosis, there is a need to develop new anti-protozoal compounds, which would either eliminate the parasite or avoid its transmission. In order to identify compounds of interest, the in vitro activities of 41 di-cationic pentamidine derivatives were studied employing a transgenic N. caninum clone expressing beta-galactosidase as a reporter gene. The arylimidamide DB745, previously …