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Biomimetic Macromolecules For Macrophage Targeting And Modulation, Joshua Whited
Biomimetic Macromolecules For Macrophage Targeting And Modulation, Joshua Whited
ETD Archive
Carbohydrate recognition has come to the forefront of biological aiming to uncover the mechanisms of physiological and pathological processes. Cell surface glycans are involved in processes including cellular adhesion, cell signaling, and immune response. A new approach for profiling cell surface glycans has great potential for a wide range of biomedical applications. Lectins have been conventionally used to determine the structure and function of glycoproteins, however, their numbers are still restricted compared to the number of glycan structures. Boronic acid has proven a remarkable small molecule capable of binding diols in aqueous solution. This interaction indicates boronic acid derived molecules …
The Role Of Rnase L In Type I Diabetes And Development Of Quantitative Lc-Ms/Ms Methods For The Pharmacological Studies Of Anti-Cancer Drug Candidates, Chun Zeng
ETD Archive
PROJECT I: The cause of type I diabetes continues to be a focus of investigation. In this study, we found that 2-5A dependent RNase L (RNase L), an IFN-a-inducible enzyme that functions in IFN action against viruses and cell proliferation, played an important role in dsRNA-induced onset of type I diabetes. By using RNase L deficient RIP-B7.1 mice which are more vulnerable to environmental harmful factors such as viral infection, we demonstrated that deficiency of RNase L in mice resulted in a significant delay of diabetes onset induced by polyinosinic:polycytidylic acid (poly I:C), a type of dsRNA, and streptozotocin (STZ). …
The Role Of Platelets In Hyaluronan Degradation, Sami Albeiroti
The Role Of Platelets In Hyaluronan Degradation, Sami Albeiroti
ETD Archive
Following tissue injury, platelets rapidly interact with the exposed extracellular matrix (ECM) of blood vessel wall and the surrounding tissues. Hyaluronan (HA) is a major polysaccharide component of the ECM and plays a significant role in regulating inflammation. Human platelets can degrade HA from the surfaces of activated endothelial cells into fragments capable of inducing immune responses by monocytes. In addition, platelets contain the enzyme hyaluronidse-2 (HYAL2), one of two major hyaluronidases that digest HA in somatic tissues. The deposition of HA increases in the inflamed tissues in several inflammatory diseases, including Inflammatory Bowel Disease (IBD). This study provides evidence …
Singing Behavior And Geographic Variation In The Songs Of The Veery (Catharus Fuscescens) Across The Appalachian Mountains, Courtney L. Brennan
Singing Behavior And Geographic Variation In The Songs Of The Veery (Catharus Fuscescens) Across The Appalachian Mountains, Courtney L. Brennan
ETD Archive
The Veery (Catharus fuscescens) is a common Neotropical migrant thrush whose breeding distribution spans the Northern United States and southern Canada and continues south through the high elevations of the Appalachian Mountains. Despite its wide distribution, many aspects of Veery biology are largely unknown, including a clear characterization of song and knowledge of geographic song variation. I describe the song structure, repertoire size, and patterns of song delivery in the songs of the Veery and describe geographic song variation across four regions along the Appalachian Mountains. Visual analysis of song spectrogram images of territorial males revealed that Veeries' repertoire ranges …