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Physical Sciences and Mathematics
City University of New York (CUNY)
Bifunctional Chelator; DFO; HOPO; Ligands; Positron Emission Tomography; Zirconium-89
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Zirconium-89: Radiochemistry And Ligand Development Toward Improved Pet Applications, Melissa Ann Deri
Zirconium-89: Radiochemistry And Ligand Development Toward Improved Pet Applications, Melissa Ann Deri
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Antibodies are attractive targeting vectors for positron emission tomography (PET) based imaging agents due to their high affinity and selectivity to a variety of biological targets. Creating such imaging agents requires a radionuclide with suitable decay characteristics. This role has been filled by zirconium-89 which has a 78.41 h half-life that ideally matches the multi-day biological half-life of IgG antibodies.
However, the use of a radiometal necessitates the use of a bifunctional chelator to bind the metal and conjugate to the antibody. For 89Zr this has been the purview of various derivatives of desferrioxamine B (DFO); however, the observed …