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A Comparison Of Computational Approaches For Intron Retention Detection, Jiantao Zheng, Cuixiang Lin, Zhenpeng Wu, Hong-Dong Li
A Comparison Of Computational Approaches For Intron Retention Detection, Jiantao Zheng, Cuixiang Lin, Zhenpeng Wu, Hong-Dong Li
Big Data Mining and Analytics
Intron Retention (IR) is an alternative splicing mode through which introns are retained in mature RNAs rather than being spliced in most cases. IR has been gaining increasing attention in recent years because of its recognized association with gene expression regulation and complex diseases. Continuous efforts have been dedicated to the development of IR detection methods. These methods differ in their metrics to quantify retention propensity, performance to detect IR events, functional enrichment of detected IRs, and computational speed. A systematic experimental comparison would be valuable to the selection and use of existing methods. In this work, we conduct an …
Computational Approaches For Finding Disease Related Genes And Rnas, Negin Fraidouni
Computational Approaches For Finding Disease Related Genes And Rnas, Negin Fraidouni
Computer Science and Engineering Dissertations
Finding candidate genes that could cause specific diseases has been the subject of many studies. This is an important research task, however in the biological experimentation domain it can be very expensive and time consuming. So an alternative way is to find gene expression values from partial measurements and try to predict the rest. By using computational methods, we can statistically estimate these relationships faster and in a more efficient way, providing domain experts suggestions on what exploration of likely relationships they should be focusing. One common computational approach is to model the gene expression data as a matrix (where …