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Data On Licensed Pharmacists, Utah, 1979

Health

This report is one of a set of State reports published by the National Center for Health Statistics (NCHS) containing data from the 1978-79 National Inventory of Pharmacists. The actual data collection ranged from mid 1977 for the first State to mid 1980 for the final State, with the majority occurring in 1978. This set of reports includes all States and the District of Columbia for which data are available.

Synthesis Of Dihydroisoquinolines And Tetrahydroisoquinolines, John J. Schlager

Chemistry & Biochemistry Theses & Dissertations

Dihydroisoquinolines and tetrahydroisoquinolines are compounds which possess a variety of pharmacological activities. New easier methods of synthetic manipulations of these structures is of constant interest in the pharmaceutical industry.

This paper describes a new three step method of preparing 1-alkyl- and 1-aryl-tetrahydroisoquinolines from a tetrahydroisoquinoline. The synthesis involves the N-chlorination of tetrahydroisoquinoline followed by dehydrohalogenation with potassium superoxide. The reaction products are the dihydroisoquinolines. Overall yields range from 85-96%. The unsubstituted, 1-methyl-, and 1-phenyl-J,4-dihydroisoquinolines have been formed. Organometallation of the unsubstituted dihydroisoquinoline provides the 1-substituted tetrahydroisoquinoline. The 1-benzyl-, 1-n-butyl-, 1-ethyl-, 1-methyl-, and 1-phenyl-1,2,J,4-tetrahydroisoquinolines were prepared. The use of Grignard and …

Nasal Administration Of Propranolol, Anwar A. Hussain, Shinichiro Hirai, Rima Bawarshi

Pharmaceutical Sciences Faculty Patents

The invention relates to a novel method of administering propranolol, a known β-andrenergic blocking agent widely used in the treatment of angina pectoris, arrhythmias, hypertension and other cardiac conditions, and migraine. The invention further relates to novel dosage forms of propranolol which are adapted for nasal administration and which include solutions, suspensions, gels and ointments.

Testing The Integrity Of Liquid Containing Hermetically Sealed Containers By The Use Of Radioactive Markers, Patrick P. Deluca, L. David Butler

Pharmaceutical Sciences Faculty Patents

A method for detecting leaky ampules filled with a liquid such as a parenteral solution. The ampules to be tested are immersed in a solution containing a short-lived radionuclide, and a pressure differential is imposed between the solution containing the radionuclide and the parenteral solution or other liquid contained in the ampules. The ampules are then removed from solution, decontaminated to remove any solution adhering to the outer surface and pores thereof, dried, and finally examined for electromagnetic radiation, preferably gamma radiation, emanating from the interior of the ampules which would indicate a leaky condition thereof.

Synthesis And Use Of Diagnostic Radio-Pharmaceuticals Comprising Radioactive Isotopes Of Bromine With Dyes, John W. Triplett, Randall B. Smith

Pharmaceutical Sciences Faculty Patents

A process for preparing bromine-containing dyes labelled with gamma-emitting isotopes of bromine, and the product thereof which is useful as an imaging agent for the hepato-biliary system, particularly in dynamic imaging methods. The dyes prepared are from the class of triarylmethane dyes, and also from the phthalein subclass of the class of xanthene dyes, and the labelling thereof is effected with ⁷⁶Br, ⁷⁷ Br or ⁸² Br. The process for preparing these dyes involves reacting the non-brominated dye precursor with either ⁷⁶ Br₂, ⁷⁷ Br₂ or ⁸² Br₂. This is a substitution type of …

Winter 1981, Southwestern Oklahoma State University

The Sig

The Sig Newsletter from the Southwestern Oklahoma State University College of Pharmacy - Winter 1981

Synthesis And Biological Evaluation Of Sparsomycin Analogues, Scherer Preston Sanders

Theses and Dissertations

In 1962, Owen, Dietz, and Camiener reported the isolation of a new antitumor antibiotic from the culture filtrate of Streptomyces sparsogenes. The structure of the crystalline antibiotic, named sparsomycin, remained elusive until 1970, when Wiley and MacKellar reported results of spectroscopic and degradation studies which elucidated the structure. In addition to the molecular structure, investigators have examined the mechanism of action, toxicity, and related analogues, striving to establish sparsomycin or a synthetic analogue's usefulness as an effective chemotherapeutic agent.

The initial pharmacological evaluation of sparsomycin revealed it possessed activity against KB human epidermoid carcinoma cells, a variety of gram-negative and …

Release Of Cortisol From Propylene Glycol Monostearate--Ethoxylated Stearyl Alcohol Films, Conway Ko-Huri Chou

University of the Pacific Theses and Dissertations

In the present study, propylene glycol monostearate (PGM), ethoxylated stearyl alcohol (ESA) and combination thereof have been investigated for their film-forming potential. The wettability, strength, and integrity of the films were evaluated by measuring the contact angles and modulus of elasticity. The films of mixed composition had smaller contact angles than the films of either component. The modulus of elasticity of all films tested was in the range of 0.19 - 0.40 Kg/cm². A series of experiments were conducted in vitro to study the effect of changes in film composition, drug concentration and rate of agitation on cortisol …

Toxicology And Pharmacology Of N¹-Acetylspermidine And N⁸-Acetylspermidine, Othman A. Alshabanah

University of the Pacific Theses and Dissertations

The polyamines are a group of natural compounds which have been found in almost all living tissues. N¹- and N⁸- acetylspermidine have been known for a considerable time as normal constituents in human urine, but their physiological role is unknown. Recent studies have indicated the presence of enzymes in the tissues capable of converting spermidine into N¹-acetylspermidine and N⁸-acetylspermidine and other enzyme activities which catalyze deacetylation and interconversion reactions.

One approach for determining physiologic activity of an endogenous compound is to observe their pharmacologic and toxicologic effects. In the present study, the …

In Vitro Percutaneous Penetration Of Methotrexate, Rajaram Vaidyanathan

University of the Pacific Theses and Dissertations

This research project was designed to investigate the effects of various physical and chemical parameters on percutaneous penetration of methotrexate. The potential of propylene glycol in water as a vehicle for topical delivery of methotrexate has been examined. A detailed examination of solubility, partition coefficient and pH parameters in the range of 2 to 6 pH units has been conducted with the goal of correlating their effects on skin penetration of methotrexate. The importance of physiochemical parameters such as solubility and partition coefficient and their aid in the development of a suitable delivery system for topical application has been explained. …

1981 Apothecary, Southwestern Oklahoma State University

Apothecary

THE APOTHECARY would like to congratulate the Seniors on the completion of five years of hard work. We have learned much about our profession and accept the challenges of a professional pharmacist - to be leaders in the advancement of our profession.