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Behavioral Economic Demand: Investigation Of Sex Differences In Four Core Genotype Model Of Oral Oxycodone Self-Administration, Michelle Elsmore, David Jentsch, Joshua Peck, Anushree Karkhanis

Undergraduate Honors Theses

Opioid misuse has been identified to be related to problematic release of dopamine in the brain that is otherwise satiated by other alternative rewards. As mediated by patterns of positive and negative reinforcement, prolonged opioid use may transition into misuse and development of opioid use disorder. In human populations, men and women differ in their acquisition of drug use and escalation to drug misuse. Women quickly surpass their male counterparts in their transition from use to misuse in what is coined the telescoping effect. In this four core genotype model of oral oxycodone self administration, males were hypothesized to consume …