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Cardioprotective Role Of The Cholinergic System, Mouhamed Dakroub
Cardioprotective Role Of The Cholinergic System, Mouhamed Dakroub
Electronic Thesis and Dissertation Repository
The process of aging is an irreversible continuum experienced by all individuals. A large number of physiological transformations occur to the cardiovascular system as one ages. These changes result in increased risk of developing cardiovascular diseases, many of which are frequently seen in geriatric populations. While the exact mechanisms of age-related cardiac dysfunction have not been established, abnormal cholinergic dysfunction has been implicated in the pathology of other age related diseases; therefore, we have hypothesized that age induced cholinergic dysfunction is detrimental to cardiac function and health. This study seeks to identify whether increased cholinergic signaling, either by transgenic overexpression …
Aging And Obesity Models In Osteoarthritis, Sara Ohora
Aging And Obesity Models In Osteoarthritis, Sara Ohora
Electronic Thesis and Dissertation Repository
Osteoarthritis (OA) is a degenerative joint disease whose exact mechanisms are not well understood, but aging and obesity are common risk factors. To determine the role of transforming growth factor-alpha (TGFα) in obesity-associated OA, Tgfa null and control mice on control and high fat diets were compared. In addition, spontaneous OA was investigated in aging C57BL/6J mice. Quantitative magnetic resonance was used to assess body composition in the obesity model, while gait analysis, histological staining and OARSI scoring were used to determine OA in both models. Mice on high fat diet developed no OA, but Tgfa null mice weighed significantly …