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Articles 1 - 8 of 8
Full-Text Articles in Entire DC Network
A Metagenomic Approach To Evaluating Surface Water Quality In Haiti, Monika A. Roy, Jean M. Arnaud, Paul M. Jasmin, Steve Hamner, Nur A. Hasan, Rita R. Colwell, Timothy E. Ford
A Metagenomic Approach To Evaluating Surface Water Quality In Haiti, Monika A. Roy, Jean M. Arnaud, Paul M. Jasmin, Steve Hamner, Nur A. Hasan, Rita R. Colwell, Timothy E. Ford
Environmental Health Sciences Faculty Publication Series
The cholera epidemic that occurred in Haiti post-earthquake in 2010 has resulted in over 9000 deaths during the past eight years. Currently, morbidity and mortality rates for cholera have declined, but cholera cases still occur on a daily basis. One continuing issue is an inability to accurately predict and identify when cholera outbreaks might occur. To explore this surveillance gap, a metagenomic approach employing environmental samples was taken. In this study, surface water samples were collected at two time points from several sites near the original epicenter of the cholera outbreak in the Central Plateau of Haiti. These samples underwent …
Developmental Exposure To 2,2′,4,4′-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance Of Lipids In Male Mice, Ahmed Khalil, Sebnem Eren Cevik, Stephanie Hung, Sridurgadevi Kolla, Monika Roy, Alexander Suvorov
Developmental Exposure To 2,2′,4,4′-Tetrabromodiphenyl Ether Permanently Alters Blood-Liver Balance Of Lipids In Male Mice, Ahmed Khalil, Sebnem Eren Cevik, Stephanie Hung, Sridurgadevi Kolla, Monika Roy, Alexander Suvorov
Environmental Health Sciences Faculty Publication Series
Polybrominated diphenyl ethers (PBDEs) were used as flame-retardant additives starting 1965 and were recently withdrawn from commerce in North America and Europe. Approximately 1/5 of the total U.S. population were born when environmental concentrations of PBDE plateaued at their maximum. Accumulating evidence suggests that developmental exposures to PBDE may result in long-lasting programming of liver metabolism. In this study, CD-1 mice were exposed prenatally or neonatally to 1 mg/kg body weight of 2,2′ ,4,4′ -tetrabromodiphenyl ether (BDE-47), and changes in liver histology, transcriptome, and liver-blood balance of triglycerides were analyzed in 10 months old male offspring. In both exposure groups, …
Oxybenzone Alters Mammary Gland Morphology In Mice Exposed During Pregnancy And Lactation, Charlotte D. Laplante, Ruby Bansal, Karen A. Dunphy, D. Joseph Jerry, Laura N. Vandenberg
Oxybenzone Alters Mammary Gland Morphology In Mice Exposed During Pregnancy And Lactation, Charlotte D. Laplante, Ruby Bansal, Karen A. Dunphy, D. Joseph Jerry, Laura N. Vandenberg
Environmental Health Sciences Faculty Publication Series
Hormones and endocrine-disrupting chemicals are generally thought to have permanent “organizational” effects when exposures occur during development but not adulthood. Yet, an increasing number of studies have shown that pregnant females are disrupted by endocrine-disrupting chemical exposures, with some effects that are permanent. Here, we examined the long-term effects of exposure to oxybenzone, an estrogenic chemical found in sunscreen and personal care products, on the morphology of the mammary gland in mice exposed during pregnancy and lactation. Female mice were exposed to vehicle or 30, 212, or 3000 µg oxybenzone/kg/d, from pregnancy day 0 until weaning. A nulliparous group, receiving …
Hormesis: Path And Progression To Significance, Edward J. Calabrese
Hormesis: Path And Progression To Significance, Edward J. Calabrese
Environmental Health Sciences Faculty Publication Series
This paper tells the story of how hormesis became recognized as a fundamental concept in biology, affecting toxicology, microbiology, medicine, public health, agriculture, and all areas related to enhancing biological performance. This paper assesses how hormesis enhances resilience to normal aging and protects against a broad spectrum of neurodegenerative, cardiovascular, and other diseases, as well as trauma and other threats to health and well-being. This paper also explains the application of hormesis to several neurodegenerative diseases such as Parkinson’s and Huntington’s disease, macrophage polarization and its systematic adaptive protections, and the role of hormesis in enhancing stem cell functioning and …
Transcriptomic Analysis Of Gonadal Adispose Tissue In Male Mice Exposed Perinatally To 2,2',4,4'-Tetrabromodiphenyl Ether (Bde-47), Aser Abrha, Alexander Suvorov
Transcriptomic Analysis Of Gonadal Adispose Tissue In Male Mice Exposed Perinatally To 2,2',4,4'-Tetrabromodiphenyl Ether (Bde-47), Aser Abrha, Alexander Suvorov
Environmental Health Sciences Faculty Publication Series
For the majority of lipophilic compounds, adipose tissue is traditionally considered as a storage depot and only rarely as a target organ. Meanwhile, abnormalities in adipose tissue physiology induced by chemical exposure may contribute to the current epidemic of obesity and metabolic diseases. Polybrominated diphenyl ethers (PBDEs) are a group of lipophilic flame retardants found in the majority of human samples in North America. Their ability to alter the physiology of adipose tissue is unknown. We exposed pregnant mice to 0.2 mg/kg body weight/day of BDE-47 perinatally. Transcriptomic changes in gonadal adipose tissue were analyzed in male offspring using the …
Transcriptomic Analysis Of Gonadal Adipose Tissue In Male Mice Exposed Perinatally To 2,2′,4,4′-Tetrabromodiphenyl Ether (Bde-47), Aser Abrha, Alexander Suvorov
Transcriptomic Analysis Of Gonadal Adipose Tissue In Male Mice Exposed Perinatally To 2,2′,4,4′-Tetrabromodiphenyl Ether (Bde-47), Aser Abrha, Alexander Suvorov
Environmental Health Sciences Faculty Publication Series
For the majority of lipophilic compounds, adipose tissue is traditionally considered as a storage depot and only rarely as a target organ. Meanwhile, abnormalities in adipose tissue physiology induced by chemical exposure may contribute to the current epidemic of obesity and metabolic diseases. Polybrominated diphenyl ethers (PBDEs) are a group of lipophilic flame retardants found in the majority of human samples in North America. Their ability to alter the physiology of adipose tissue is unknown. We exposed pregnant mice to 0.2 mg/kg body weight/day of BDE-47 perinatally. Transcriptomic changes in gonadal adipose tissue were analyzed in male offspring using the …
Nanoparticle Exposure And Hormetic Dose–Responses: An Update, Ivo Iavicoli, Versucka Leso, Luca Fontana, Edward J. Calabrese
Nanoparticle Exposure And Hormetic Dose–Responses: An Update, Ivo Iavicoli, Versucka Leso, Luca Fontana, Edward J. Calabrese
Environmental Health Sciences Faculty Publication Series
The concept of hormesis, as an adaptive response of biological systems to moderate environmental challenges, has raised considerable nano-toxicological interests in view of the rapid pace of production and application of even more innovative nanomaterials and the expected increasing likelihood of environmental and human exposure to low-dose concentrations. Therefore, the aim of this review is to provide an update of the current knowledge concerning the biphasic dose–responses induced by nanoparticle exposure. The evidence presented confirmed and extended our previous findings, showing that hormesis is a generalized adaptive response which may be further generalized to nanoscale xenobiotic challenges. Nanoparticle physico-chemical properties …
Community Engaged Cumulative Risk Assessment Of Exposure To Inorganic Well Water Contaminants, Crow Reservation, Montana, Margaret J. Eggers, John T. Doyle, Myra J. Lefthand, Sara L. Young, Anita L. Moore-Nall, Larry Kindness, Roberta Other Medicine, Timothy E. Ford, Eric Dietrich, Albert E. Parker, Joseph H. Hoover, Anne K. Camper
Community Engaged Cumulative Risk Assessment Of Exposure To Inorganic Well Water Contaminants, Crow Reservation, Montana, Margaret J. Eggers, John T. Doyle, Myra J. Lefthand, Sara L. Young, Anita L. Moore-Nall, Larry Kindness, Roberta Other Medicine, Timothy E. Ford, Eric Dietrich, Albert E. Parker, Joseph H. Hoover, Anne K. Camper
Environmental Health Sciences Faculty Publication Series
An estimated 11 million people in the US have home wells with unsafe levels of hazardous metals and nitrate. The national scope of the health risk from consuming this water has not been assessed as home wells are largely unregulated and data on well water treatment and consumption are lacking. Here, we assessed health risks from consumption of contaminated well water on the Crow Reservation by conducting a community-engaged, cumulative risk assessment. Well water testing, surveys and interviews were used to collect data on contaminant concentrations, water treatment methods, well water consumption, and well and septic system protection and maintenance …