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Operations Research, Systems Engineering and Industrial Engineering
Biomedical, Industrial & Human Factors Engineering Faculty Publications
- Keyword
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- Functional Near-Infrared Spectroscopy (3)
- Activation (1)
- Cancellous core stress (1)
- Cervical spine (1)
- Children and Adolescents (1)
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- Enzyme Replacement Therapy (1)
- Finger Tapping (1)
- Finite element modeling (1)
- Fracture (1)
- Gaucher Disease (1)
- Glenoid liners (1)
- Hallux toe (1)
- Hand Grasping (1)
- Hemi-Toe (1)
- Human factors issues in damage assessment (1)
- Metophalengeal joint (1)
- Motor Cortex (1)
- Motor Stimulation (1)
- Near Infrared Spectroscopy (1)
- Near-Infrared Spectroscopy (1)
- Neonates (1)
- Pediatric Patients (1)
- Retrieved liner analysis (1)
- Somatic Stimulation (1)
- Subsidence (1)
- Total composite damage (1)
- Velaglucerase Alfa (1)
- Vertebral Endplates (1)
- Visual Cortex (1)
- Visual Stimulation (1)
Articles 1 - 7 of 7
Full-Text Articles in Entire DC Network
Somatic Stimulation Causes Frontoparietal Cortical Changes In Neonates: A Functional Near-Infrared Spectroscopy Study, Nasser H. Kashou, Irfaan Akram Dar, Kathryn Hasenstab, Ramzi W. Nahhas, Sudarshan R. Jadcherla
Somatic Stimulation Causes Frontoparietal Cortical Changes In Neonates: A Functional Near-Infrared Spectroscopy Study, Nasser H. Kashou, Irfaan Akram Dar, Kathryn Hasenstab, Ramzi W. Nahhas, Sudarshan R. Jadcherla
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Palmar and plantar grasp are the foremost primitive neonatal reflexes and functions. Persistence of these reflexes in infancy is a sign of evolving cerebral palsy. Our aims were to establish measurement feasibility in a clinical setting and to characterize changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbD) concentration in the bilateral frontoparietal cortex in unsedated neonates at the crib-side using functional near-infrared spectroscopy (fNIRS). We hypothesized that bilateral concentration changes will occur upon somatic central and peripheral somatic stimulation. Thirteen preterm neonates (five males) underwent time 1, and six (two males) returned for time 2 (mean PMA ¼ 41.6 and 47.0 …
Quantitative Analysis Of Retrieved Glenoid Liners, Katelyn Childs, Lynn Crosby, Tarun Goswami
Quantitative Analysis Of Retrieved Glenoid Liners, Katelyn Childs, Lynn Crosby, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Revision of orthopedic surgeries is often expensive and involves higher risk from complications. Since most total joint replacement devices use a polyethylene bearing, which serves as a weak link, the assessment of damage to the liner due to in vivo exposure is very important. The failures often are due to excessive polyethylene wear. The glenoid liners are complex and hemispherical in shape and present challenges while assessing the damage. Therefore, the study on the analysis of glenoid liners retrieved from revision surgery may lend insight into common wear patterns and improve future product designs. The purpose of this pilot study …
Long-Term Velaglucerase Alfa Treatment In Children With Gaucher Disease Type 1 Naïve To Enzyme Replacement Therapy Or Previously Treated With Imiglucerase, Laurie Smith, William Rhead, Joel Charrow, Suma P. Shankar, Ashish Bavdekar, Nicola Longo, Rebecca Mardach, Paul Harmatz, Thomas N. Hangartner, Hak-Myung Lee, Eric Crombez, Gregory M. Pastores
Long-Term Velaglucerase Alfa Treatment In Children With Gaucher Disease Type 1 Naïve To Enzyme Replacement Therapy Or Previously Treated With Imiglucerase, Laurie Smith, William Rhead, Joel Charrow, Suma P. Shankar, Ashish Bavdekar, Nicola Longo, Rebecca Mardach, Paul Harmatz, Thomas N. Hangartner, Hak-Myung Lee, Eric Crombez, Gregory M. Pastores
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Background
Gaucher Disease type 1 (GD1) often manifests in childhood. Early treatment with enzyme replacement therapy (ERT) may prevent disease complications. We report the assessment of velaglucerase alfa ERT in pediatric GD1 patients who participated in a long-term extension study (HGT-GCB-044, ClinicalTrials.gov Identifier NCT00635427).
Methods
Safety and efficacy were evaluated in pediatric patients receiving velaglucerase alfa 30–60 U/kg by intravenous infusion every other week. In addition to key hematological and visceral efficacy assessments, exploratory assessments conducted specifically in pediatric patients included evaluation of height, bone age, bone marrow burden, and Tanner stage of puberty.
Results
The study included 24 …
Hand-Grasping And Finger Tapping Induced Similar Functional Near-Infrared Spectroscopy Cortical Responses, Nasser H. Kashou, Brenna M. Giacherio, Ramzi W. Nahhas, Sudarshan R. Jadcherla
Hand-Grasping And Finger Tapping Induced Similar Functional Near-Infrared Spectroscopy Cortical Responses, Nasser H. Kashou, Brenna M. Giacherio, Ramzi W. Nahhas, Sudarshan R. Jadcherla
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Despite promising advantages such as low cost and portability of functional near-infrared spectroscopy (fNIRS), it has yet to be widely implemented outside of basic research. Specifically, fNIRS has yet to be proven as a standalone tool within a clinical setting. The objective of this study was to assess hemodynamic concentration changes at the primary and premotor motor cortices as a result of simple whole-hand grasping and sequential finger-opposition (tapping) tasks. These tasks were repeated over 3 days in a randomized manner. Ten healthy young adults (23.8 4.8 years) participated in the study. Quantitatively, no statistically significant differences were discovered between …
Finite Element Analysis Of Superior C3 Cervical Vertebra Endplate And Cancellous Core Under Static Loads, Isaac Mabe, Tarun Goswami
Finite Element Analysis Of Superior C3 Cervical Vertebra Endplate And Cancellous Core Under Static Loads, Isaac Mabe, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Subsidence is a type of failure associated with implanted cervical cages or artificial intervertebral discs. It is defined as a loss of postoperative disc height. Actuarial rates show a risk of subsidence at 16 weeks at 70.7 percent. This study examines the changes in the vertebral endplate morphology and the resulting effect on the stresses developed in the endplate and in the vertebral core. A three-dimensional linear elastic model was created from computed tomographic (CT) scans and material properties were assigned according to various studies. Particular care was taken in the superior endplate that was modeled according to experimental measurements. …
Stimulus And Optode Placement Effects On Functional Near-Infrared Spectroscopy Of Visual Cortex, Nasser H. Kashou, Brenna M. Giacherio
Stimulus And Optode Placement Effects On Functional Near-Infrared Spectroscopy Of Visual Cortex, Nasser H. Kashou, Brenna M. Giacherio
Biomedical, Industrial & Human Factors Engineering Faculty Publications
Functional near-infrared spectroscopy has yet to be implemented as a stand-alone technique within an ophthalmology clinical setting, despite its promising advantages. The present study aims to further investigate reliability of visual cortical signals. This was achieved by: (1) assessing the effects of optode placements using the 10–20 International System of Electrode Placement consisting of 28 channels, (2) determining effects of stimulus size on response, and (3) evaluating response variability as a result of cap placement across three sessions. Ten participants with mean age 23.8 4.8 years (five male) and varying types of hair color and thickness were recruited. Visual stimuli …
Analysis Of A Clinically Failed, Mechanically Intact, Hemi-Toe Implant, Swetha Varadharajan, Richard T. Laughlin, Tarun Goswami
Analysis Of A Clinically Failed, Mechanically Intact, Hemi-Toe Implant, Swetha Varadharajan, Richard T. Laughlin, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
In this case study a clinically failed, mechanically intact, hemi-toe device was investigated. The clinical indication of the failure constitutes radiolucent line indicating loosening of the implant and possible interactions among the bone-implant initiated by osteolysis may become a factor, producing pain, inflammatory reactions, deformity and discomfort. The patient file was not available to determine these parameters. The device was titanium coated, Cobalt Chromium alloy used for making hemi-toe. Degeneration of hemi implant was due to spalling of the coating from the surface, causing loosening of stem from bone. However, pre-removal X-ray films were not available to confirm. Mechanism by …