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Articles 1 - 11 of 11
Full-Text Articles in Entire DC Network
Specific Contributions Of Ventromedial, Anterior Cingulate, And Lateral Prefrontal Cortex For Attentional Selection And Stimulus Valuation., Daniel Kaping, Martin Vinck, R Matthew Hutchison, Stefan Everling, Thilo Womelsdorf
Specific Contributions Of Ventromedial, Anterior Cingulate, And Lateral Prefrontal Cortex For Attentional Selection And Stimulus Valuation., Daniel Kaping, Martin Vinck, R Matthew Hutchison, Stefan Everling, Thilo Womelsdorf
Brain and Mind Institute Researchers' Publications
Attentional control ensures that neuronal processes prioritize the most relevant stimulus in a given environment. Controlling which stimulus is attended thus originates from neurons encoding the relevance of stimuli, i.e. their expected value, in hand with neurons encoding contextual information about stimulus locations, features, and rules that guide the conditional allocation of attention. Here, we examined how these distinct processes are encoded and integrated in macaque prefrontal cortex (PFC) by mapping their functional topographies at the time of attentional stimulus selection. We find confined clusters of neurons in ventromedial PFC (vmPFC) that predominantly convey stimulus valuation information during attention shifts. …
Paradoxical Reversal Learning Enhancement By Stress Or Prefrontal Cortical Damage: Rescue With Bdnf., Carolyn Graybeal, Michael Feyder, Emily Schulman, Lisa M Saksida, Timothy J Bussey, Jonathan L Brigman, Andrew Holmes
Paradoxical Reversal Learning Enhancement By Stress Or Prefrontal Cortical Damage: Rescue With Bdnf., Carolyn Graybeal, Michael Feyder, Emily Schulman, Lisa M Saksida, Timothy J Bussey, Jonathan L Brigman, Andrew Holmes
Brain and Mind Institute Researchers' Publications
Stress affects various forms of cognition. We found that moderate stress enhanced late reversal learning in a mouse touchscreen-based choice task. Ventromedial prefrontal cortex (vmPFC) lesions mimicked the effect of stress, whereas orbitofrontal and dorsolateral striatal lesions impaired reversal. Stress facilitation of reversal was prevented by BDNF infusion into the vmPFC. These findings suggest a mechanism by which stress-induced vmPFC dysfunction disinhibits learning by alternate (for example, striatal) systems.
Principles Of Sensorimotor Learning., Daniel M Wolpert, Jörn Diedrichsen, J Randall Flanagan
Principles Of Sensorimotor Learning., Daniel M Wolpert, Jörn Diedrichsen, J Randall Flanagan
Brain and Mind Institute Researchers' Publications
The exploits of Martina Navratilova and Roger Federer represent the pinnacle of motor learning. However, when considering the range and complexity of the processes that are involved in motor learning, even the mere mortals among us exhibit abilities that are impressive. We exercise these abilities when taking up new activities - whether it is snowboarding or ballroom dancing - but also engage in substantial motor learning on a daily basis as we adapt to changes in our environment, manipulate new objects and refine existing skills. Here we review recent research in human motor learning with an emphasis on the computational …
Effects Of Methamphetamine On Sexual Behavior, Karla S. Frohmader
Effects Of Methamphetamine On Sexual Behavior, Karla S. Frohmader
Electronic Thesis and Dissertation Repository
Methamphetamine (Meth) is a highly addictive psychostimulant associated with enhanced sexual desire, arousal, and sexual pleasure. Moreover, Meth abuse is frequently linked with the practice of sexual risk behavior and increased prevalence of Human Immunodeficiency Virus (HIV). Currently, the neurobiological basis for this drug-sex nexus is unknown. Moreover, there is a lack of studies investigating the effects of Meth on sexual behavior and more importantly, compulsive sex-seeking behavior, under controlled experimental settings in animal models. First, using immuhistochemistry for mating- and Meth-induced neural activation it was demonstrated that Meth administration in male rats activates neurons in brain regions of the …
Decoding Motor Intentions From Human Brain Activity, Jason P. Gallivan
Decoding Motor Intentions From Human Brain Activity, Jason P. Gallivan
Electronic Thesis and Dissertation Repository
“You read my mind.” Although this simple everyday expression implies ‘knowledge or understanding’ of another’s thinking, true ‘mind-reading’ capabilities implicitly seem constrained to the domains of Hollywood and science-fiction. In the field of sensorimotor neuroscience, however, significant progress in this area has come from mapping characteristic changes in brain activity that occur prior to an action being initiated. For instance, invasive neural recordings in non-human primates have significantly increased our understanding of how highly cognitive and abstract processes like intentions and decisions are represented in the brain by showing that it is possible to decode or ‘predict’ upcoming sensorimotor …
The Levels Of Analysis Revisited., Scott A Macdougall-Shackleton
The Levels Of Analysis Revisited., Scott A Macdougall-Shackleton
Brain and Mind Institute Researchers' Publications
The term levels of analysis has been used in several ways: to distinguish between ultimate and proximate levels, to categorize different kinds of research questions and to differentiate levels of reductionism. Because questions regarding ultimate function and proximate mechanisms are logically distinct, I suggest that distinguishing between these two levels is the best use of the term. Integrating across levels in research has potential risks, but many benefits. Consideration at one level can help generate novel hypotheses at the other, define categories of behaviour and set criteria that must be addressed. Taking an adaptationist stance thus strengthens research on proximate …
Prefrontal Cortex Deactivation In Macaques Alters Activity In The Superior Colliculus And Impairs Voluntary Control Of Saccades, Michael J. Koval, Stephen G. Lombar, Stefan Everling
Prefrontal Cortex Deactivation In Macaques Alters Activity In The Superior Colliculus And Impairs Voluntary Control Of Saccades, Michael J. Koval, Stephen G. Lombar, Stefan Everling
Brain and Mind Institute Researchers' Publications
The cognitive control of action requires both the suppression of automatic responses to sudden stimuli and the generation of behavior specified by abstract instructions. Though patient, functional imaging and neurophysiological studies have implicated the dorsolateral prefrontal cortex (dlPFC) in these abilities, the mechanism by which the dlPFC exerts this control remains unknown. Here we examined the functional interaction of the dlPFC with the saccade circuitry by deactivating area 46 of the dlPFC and measuring its effects on the activity of single superior colliculus neurons in monkeys performing a cognitive saccade task. Deactivation of the dlPFC reduced preparatory activity and increased …
The Effect Of Dopamine Therapy On Ventral And Dorsal Striatum-Mediated Cognition In Parkinson's Disease: Support From Functional Mri., Penny A Macdonald, Alex A Macdonald, Ken N Seergobin, Ruzbeh Tamjeedi, Hooman Ganjavi, Jean-Sebastien Provost, Oury Monchi
The Effect Of Dopamine Therapy On Ventral And Dorsal Striatum-Mediated Cognition In Parkinson's Disease: Support From Functional Mri., Penny A Macdonald, Alex A Macdonald, Ken N Seergobin, Ruzbeh Tamjeedi, Hooman Ganjavi, Jean-Sebastien Provost, Oury Monchi
Brain and Mind Institute Researchers' Publications
The central aim of our study was to elucidate functions mediated by the ventral and dorsal striatum, respectively, to better understand the cognitive effects of dopamine replacement in Parkinson's disease. We proposed that the ventral striatum underlies general learning of stimulus associations, whereas the dorsal striatum promotes integration of various influences on selecting. In Parkinson's disease, dopamine depletion is substantially less notable in the ventral relative to the dorsal striatum, and therefore greater improvements are expected for dorsal striatum-mediated functions with dopamine replacement. Using a simple selection task, we found that dopamine replacement impaired encoding and facilitation of consistent stimulus-stimulus …
Fluid Percussion Injury In The Rat As An Animal Model Of Concussion: Cumulative Effects Of Repeated Concussion And Its Treatment By Anti-Cd11d Antibody, Sandy Rc Shultz
Fluid Percussion Injury In The Rat As An Animal Model Of Concussion: Cumulative Effects Of Repeated Concussion And Its Treatment By Anti-Cd11d Antibody, Sandy Rc Shultz
Electronic Thesis and Dissertation Repository
Traumatic brain injury is a global health concern with limited treatment options currently available. Concussion is the most common form of traumatic brain injury, and although a single concussion rarely results in long-term neurological dysfunction, repeated concussion can result in cumulative damage and chronic neurodegenerative disease. However, little is known about the factors and mechanisms of concussion involved in these detrimental effects. Animal models provide a means to examine the factors and mechanisms involved in traumatic brain injury, as well as potential treatments, in experiments that cannot be conducted using human participants. In the present thesis a fluid percussion model …
Differential Effects Of Dopaminergic Therapies On Dorsal And Ventral Striatum In Parkinson's Disease: Implications For Cognitive Function., Penny A Macdonald, Oury Monchi
Differential Effects Of Dopaminergic Therapies On Dorsal And Ventral Striatum In Parkinson's Disease: Implications For Cognitive Function., Penny A Macdonald, Oury Monchi
Brain and Mind Institute Researchers' Publications
Cognitive abnormalities are a feature of Parkinson's disease (PD). Unlike motor symptoms that are clearly improved by dopaminergic therapy, the effect of dopamine replacement on cognition seems paradoxical. Some cognitive functions are improved whereas others are unaltered or even hindered. Our aim was to understand the effect of dopamine replacement therapy on various aspects of cognition. Whereas dorsal striatum receives dopamine input from the substantia nigra (SN), ventral striatum is innervated by dopamine-producing cells in the ventral tegmental area (VTA). In PD, degeneration of SN is substantially greater than cell loss in VTA and hence dopamine-deficiency is significantly greater in …
Negative Associations Between Corpus Callosum Midsagittal Area And Iq In A Representative Sample Of Healthy Children And Adolescents., Hooman Ganjavi, John D Lewis, Pierre Bellec, Penny A Macdonald, Deborah P Waber, Alan C Evans, Sherif Karama, The Brain Development Cooperative Group
Negative Associations Between Corpus Callosum Midsagittal Area And Iq In A Representative Sample Of Healthy Children And Adolescents., Hooman Ganjavi, John D Lewis, Pierre Bellec, Penny A Macdonald, Deborah P Waber, Alan C Evans, Sherif Karama, The Brain Development Cooperative Group
Brain and Mind Institute Researchers' Publications
Documented associations between corpus callosum size and cognitive ability have heretofore been inconsistent potentially owing to differences in sample characteristics, differing methodologies in measuring CC size, or the use of absolute versus relative measures. We investigated the relationship between CC size and intelligence quotient (IQ) in the NIH MRI Study of Normal Brain Development sample, a large cohort of healthy children and adolescents (aged six to 18, n = 198) recruited to be representative of the US population. CC midsagittal area was measured using an automated system that partitioned the CC into 25 subregions. IQ was measured using the Wechsler …