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Effect Of Neighborhood Socioeconomic Disadvantage On Brain Functional Connectivity And Structural Properties In Trauma-Exposed Adults, Elisabeth Kathleen Webb Dec 2021

Effect Of Neighborhood Socioeconomic Disadvantage On Brain Functional Connectivity And Structural Properties In Trauma-Exposed Adults, Elisabeth Kathleen Webb

Theses and Dissertations

Though there has been substantial progress towards understanding brain-behavior relationships and characterizing the neurobiology of psychiatric disorders, research has not translated as expected into novel prevention and treatment of mental health conditions. One limitation may be the emphasis on individual-level variables (e.g., income) and omission of relevant area-level factors (e.g., neighborhood socioeconomic disadvantage). Recently, attention has been directed towards identifying the biological mechanisms by which neighborhoods impact mental health. The chronic stress associated with living in a disadvantaged neighborhood promotes a cascade of maladaptive events, which in turn impact brain structure and functioning. The processes affected by chronic neighborhood stressors …


Brain Parcellation Selection: An Overlooked Decision Point With Meaningful Effects On Individual Differences In Resting-State Functional Connectivity, Nessa V. Bryce, John C. Flournoy, João F. Guassi Moreira, Maya L. Rosen, Kelly A. Sambook, Patrick Mair, Katie A. Mclaughlin Nov 2021

Brain Parcellation Selection: An Overlooked Decision Point With Meaningful Effects On Individual Differences In Resting-State Functional Connectivity, Nessa V. Bryce, John C. Flournoy, João F. Guassi Moreira, Maya L. Rosen, Kelly A. Sambook, Patrick Mair, Katie A. Mclaughlin

Neuroscience: Faculty Publications

Over the past decade extensive research has examined the segregation of the human brain into large-scale functional networks. The resulting network maps, i.e. parcellations, are now commonly used for the a priori identification of functional networks. However, the use of these parcellations, particularly in developmental and clinical samples, hinges on four fundamental assumptions: (1) the various parcellations are equally able to recover the networks of interest; (2) adult-derived parcellations well represent the networks in children's brains; (3) network properties, such as within-network connectivity, are reliably measured across parcellations; and (4) parcellation selection does not impact the results with regard to …


Intergenerational Transmission Of Functional Connectivity Profiles In Isolated Reading And Math Networks: A Scoping Review And Study Proposal, Ashini Peiris, Ira Gupta, Lien Peters, Eric D. Wilkey Aug 2021

Intergenerational Transmission Of Functional Connectivity Profiles In Isolated Reading And Math Networks: A Scoping Review And Study Proposal, Ashini Peiris, Ira Gupta, Lien Peters, Eric D. Wilkey

Undergraduate Student Research Internships Conference

The scoping review surveyed the existing literature on the topic of resting-state functional connectivity (rsFC) and mathematical cognition. The review revealed that rsFC is indicative of distinct long-term developmental trends in mathematical processing, alluding to individual differences in math abilities. Though there have been multiple studies that investigate individual differences in functional connectivity patterns related to math development and math learning disorders, no study has directly investigated to what degree these neurobiological factors are heritable. To address this topic, the following intergenerational transmission (IT) study is proposed. IT is the transfer of personal values, abilities, behaviours, and traits, from parents …


Task-Based And Resting-State Functional Connectivity In Children With Dyscalculia, Ira Gupta Aug 2021

Task-Based And Resting-State Functional Connectivity In Children With Dyscalculia, Ira Gupta

Undergraduate Student Research Internships Conference

Resting-state functional connectivity (RSFC) is a unique method in neuroimaging that measures the spontaneous neural activity as the brain is at rest, not actively undergoing any task. It is important in investigating brain patterns that result from brain regions working together throughout an individual’s development. The application of this technique has been limited in the mathematical cognition field, and thus, should be explored further. This preregistration poster focuses on the depth of the literature and studies available in regards to RSFC and math cognition through a scoping review, and then proposes a study in which task-based and resting-state functional connectivity …


Altered Network Organization And Screen Time Use In Childhood Attention-Deficit / Hyperactivity Disorder (Adhd), Elizabeth Jane Hawkey Aug 2021

Altered Network Organization And Screen Time Use In Childhood Attention-Deficit / Hyperactivity Disorder (Adhd), Elizabeth Jane Hawkey

Arts & Sciences Electronic Theses and Dissertations

Introduction: Symptoms of attention-deficit/hyperactivity disorder (ADHD) have been associated with alterations in functional connectivity involving networks in the developing brain that support optimal cognitive control. However, a clear profile of altered connectivity has yet to emerge, and it remains unclear whether changes in behavioral patterns such as screen time (ST) contribute to ADHD symptomatology and altered connectivity in networks that support cognitive control. The current study examined connectivity between large-scale networks associated with cognitive control (CC), measures of executive function (EF) which index CC, and ST in children with ADHD. Methods: Our sample included 11,874 children (ages 9-11, 52% male) …


Neurobiological Impact Of Hiv Infection And Chronic Cannabis Use, Jessica Shannon Flannery May 2021

Neurobiological Impact Of Hiv Infection And Chronic Cannabis Use, Jessica Shannon Flannery

FIU Electronic Theses and Dissertations

Neuroimaging research has identified brain alterations linked with the human immunodeficiency virus (HIV) that contribute to cognitive declines characterizing the disease. Given cannabis’s (CB’s) anti-inflammatory properties, use prevalence among people living with HIV (PLWH), and impact on neurocognition, my dissertation utilizes a between-groups study design to interrogate separate and interactive effects of HIV and CB on fMRI measures of brain activity. We investigate (1) task-based brain activity at the regional-level, (2) insular resting-state functional connectivity (rsFC) at the circuit-level, and (3) large-scale brain network interactions at the systems-level. Participants (N=114) were stratified into four groups (HIV+/CB+; HIV+/CB-; HIV-/CB+; HIV-/CB-) and …