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Effects Of The Antidepressant Drug Vortioxetine On Ventral Pallidal Neuronal Activity, Respiration, And Heart Rate In The Rat, Piper Rogers
Effects Of The Antidepressant Drug Vortioxetine On Ventral Pallidal Neuronal Activity, Respiration, And Heart Rate In The Rat, Piper Rogers
Theses and Dissertations
Major Depressive Disorder (MDD) is a mental illness that affects millions of people worldwide. People diagnosed with MDD are often prescribed antidepressant drugs. Most antidepressants increase levels of serotonin (5-hydroxytryptamine, 5-HT) in the synapses between neurons. Selective-serotonin reuptake inhibitors (SSRIs), one class of antidepressants, do this by inhibiting the reuptake of serotonin released into the synapse. Serotonin neurons from the brainstem raphe nuclei affect a wide range of areas throughout the brain. Among these areas is the ventral pallidum (VP), located in the basal forebrain. Citalopram, an SSRI, has been found to increase the firing rate of action potentials of …