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Prevention Of Dendritic And Synaptic Deficits And Cognitive Impairment With A Neurotrophic Compound, Narjes Baazaoui, Khalid Iqbal
Prevention Of Dendritic And Synaptic Deficits And Cognitive Impairment With A Neurotrophic Compound, Narjes Baazaoui, Khalid Iqbal
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Background: The use of neurotrophic factors to treat Alzheimer’s disease (AD) is hindered by their blood–brain barrier impermeability, short half-life, and severe side effects. Peptide 021 (P021) is a neurotrophic/neurogenic tetrapeptide that was derived from the most active region of the ciliary neurotrophic factor (CNTF) by epitope mapping. Admantylated glycine was added to its C-terminal to increase its blood–brain barrier permeability and decrease its degradation by exopeptidases to make it druggable. Here, we report on the preventive effect of P021 in 3 × Tg-AD, a transgenic mouse model of AD.
Methods: P021 was administered in the diet at 3 months, …