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Neuroscience and Neurobiology

Publications and Research

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2016

Soluble RAGE

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Soluble Rage Treatment Delays Progression Of Amyotrophic Lateral Sclerosis In Sod1 Mice, Judyta K. Juranek, Gurdip K. Daffu, Matthew S. Geddis, Huilin Li, Rosa Rosario, Benjamin J. Kaplan, Lauren Kelly, Ann Marie Schmidt May 2016

Soluble Rage Treatment Delays Progression Of Amyotrophic Lateral Sclerosis In Sod1 Mice, Judyta K. Juranek, Gurdip K. Daffu, Matthew S. Geddis, Huilin Li, Rosa Rosario, Benjamin J. Kaplan, Lauren Kelly, Ann Marie Schmidt

Publications and Research

The etiology of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disorder characterized by progressive muscle weakness and spasticity, remains largely unknown. Approximately 5–10% of cases are familial, and of those, 15–20% are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). Mutations of the SOD1 gene interrupt cellular homeostasis and contribute to cellular toxicity evoked by the presence of altered SOD1, along with other toxic species, such as advanced glycation end products (AGEs). AGEs trigger activation of their chief cell surface receptor, RAGE (receptor for advanced glycation end products), and induce RAGE-dependent cellular stress and inflammation in …