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Brain Parcellation Selection: An Overlooked Decision Point With Meaningful Effects On Individual Differences In Resting-State Functional Connectivity, Nessa V. Bryce, John C. Flournoy, João F. Guassi Moreira, Maya L. Rosen, Kelly A. Sambook, Patrick Mair, Katie A. Mclaughlin

Neuroscience: Faculty Publications

Over the past decade extensive research has examined the segregation of the human brain into large-scale functional networks. The resulting network maps, i.e. parcellations, are now commonly used for the a priori identification of functional networks. However, the use of these parcellations, particularly in developmental and clinical samples, hinges on four fundamental assumptions: (1) the various parcellations are equally able to recover the networks of interest; (2) adult-derived parcellations well represent the networks in children's brains; (3) network properties, such as within-network connectivity, are reliably measured across parcellations; and (4) parcellation selection does not impact the results with regard to …