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Dopamine Controls Locomotion By Modulating The Activity Of The Cholinergic Motor Neurons In C. Elegans, Andrew T. Allen
Dopamine Controls Locomotion By Modulating The Activity Of The Cholinergic Motor Neurons In C. Elegans, Andrew T. Allen
Masters Theses 1911 - February 2014
Dopamine is an important neurotransmitter in the brain, where it plays a regulatory role in the coordination of movement and cognition by acting through two classes of G protein-coupled receptors to modulate synaptic activity. In addition, it has been shown these two receptor classes can exhibit synergistic or antagonistic effects on neurotransmission. However, while the pharmacology of the mammalian dopamine receptors have been characterized in some detail, less is known about the molecular pathways that act downstream of the receptors. As in mammals, the soil nematode Caenorhabditis elegans uses two classes of dopamine receptors to control neural activity and thus …
A New Laser Pointer Driven Optical Microheater For Precise Local Heat Shock, Mike Placinta
A New Laser Pointer Driven Optical Microheater For Precise Local Heat Shock, Mike Placinta
Masters Theses 1911 - February 2014
The zebrafish has emerged as an important genetic model system for the study of vertebrate development. However, while genetics is a powerful tool for the study of early gene functions, the approach is more limited when it comes to understanding later functions of genes that have essential roles in early embryogenesis. There is thus a need to manipulate gene expression at different times, and ideally only in some regions of the developing embryo. Methods for conditional gene regulation have been established in Drosophila, C.elegans and the mouse, utilizing conditional gene activation systems such as the Gal4-UAS system (fly) and the …
Event-Related Potential Indices Of Attentional Gradients Across The Visual Field, John C. Richiedei
Event-Related Potential Indices Of Attentional Gradients Across The Visual Field, John C. Richiedei
Masters Theses 1911 - February 2014
Our lives are dominated by a complex visual world, and spatially selective attention allows us to process only the most relevant information. Previous evidence suggests that if possible locations of stimulus presentation are delineated, attention affects processing in a spatially graded manner. This gradient is seen in both behavioral measures and in visual evoked potentials (VEPs). Stimuli presented close to cued regions elicit faster responses and larger VEPs than those presented farther away. However, both position in the visual field and allocation of attention may contribute to the observed gradients. These relative contributions can be distinguished by comparing responses on …