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Articles 1 - 5 of 5
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Methodology To Investigate Protein-Protein Interactions Of Jun During Neuronal Differentiation Of Pc12 Cells, Heather L. Leskinen
Methodology To Investigate Protein-Protein Interactions Of Jun During Neuronal Differentiation Of Pc12 Cells, Heather L. Leskinen
Theses and Dissertations
In humans and other mammals, injury to the central nervous system (CNS) can cause a permanent loss of neuronal function, leading to cognitive defects, limb paralysis, and other neurological disabilities. In contrast, studies have shown that some non-mammalian vertebrates like zebrafish, have the remarkable ability to functionally regenerate axons after CNS injury by reactivating and sustaining the expression of regeneration-associated genes (RAGs). Some RAGs encode transcriptional regulators that dimerize to control downstream gene expression necessary for functional axonal recovery. Our lab has previously identified Jun as an important transcriptional regulator of regeneration after optic nerve injury in zebrafish. After axon …
Potential Moderating Impact Of Circulating Endocannabinoids On Resting State Networks And Post-Traumatic Stress Disorder, Emily Anne Albertina
Potential Moderating Impact Of Circulating Endocannabinoids On Resting State Networks And Post-Traumatic Stress Disorder, Emily Anne Albertina
Theses and Dissertations
Introduction: Traumatic injury increases risk for long-term adverse outcomes such as the development of post-traumatic stress disorder (PTSD). Research has found that risk for the development of PTSD after such an injury varies depending on individuals’ race/ethnic group and sex. Although prior work has explored relationships between injury and PTSD in these groups utilizing imaging paradigms (e.g., resting state functional connectivity) and biological paradigms (e.g., the endocannabinoid system), the relationship between these factors has been understudied. The present study explored the potential moderating effect circulating endocannabinoids may have on the relationship between resting state functional connectivity and post traumatic stress …
Investigation Of The Role Of The G-Protein-Coupled Estrogen Receptor In Memory Consolidation In Gonadectomized Male Mice, Gustavo Dalto Barroso Machado
Investigation Of The Role Of The G-Protein-Coupled Estrogen Receptor In Memory Consolidation In Gonadectomized Male Mice, Gustavo Dalto Barroso Machado
Theses and Dissertations
Estrogens are cholesterol-derived hormones that play crucial physiological and pathological roles in both sexes and across the lifespan. Many research groups have replicated the beneficial roles of 17-beta-estradiol (E2), the most potent estrogen, in memory consolidation in the past decades, even though some mechanisms are still unclear. The rapid effects of E2 in memory formation are attributed to its binding to different estrogen receptors (ER), notably the intracellular receptors ER and ER, as well as the membrane ER called G protein-coupled estrogen receptor (GPER). Previous work from our laboratory demonstrated that acute post-training infusion of E2 into the dorsal hippocampus …
The Biological Bases Of Political Attachment: Neurobiological Correlates Of Ideology And Partisanship, Carisa Bergner
The Biological Bases Of Political Attachment: Neurobiological Correlates Of Ideology And Partisanship, Carisa Bergner
Theses and Dissertations
To fully understand the foundations of political attachments in an increasingly polarized environment, political scientists must reconcile traditional theories of political attitudes and behavior with insight gained from neurobiological approaches. The purpose of this research is to investigate the neurobiological correlates of strength of political ideology and partisanship, as well as the neurobiological correlates of ideological and partisan orientation. To do so, both structural and functional neuroimaging analyses were conducted on a diverse sample of patients at a Level 1 Trauma Center. Results indicate that strong ideological attachment is significantly associated with decreased volume in the left insula, though partisan …
Does State Of Mind Predict Prototype-Based Category Learning In Older Adults?, Kana Kimura
Does State Of Mind Predict Prototype-Based Category Learning In Older Adults?, Kana Kimura
Theses and Dissertations
Category learning plays an important role in day-to-day lives across all ages, allowing us to organize related experiences, develop expectations, and determine how we behave given those expectations. Despite its importance, the current body of literature on category learning in older adults is much smaller than that of other memory domains. Thus, little is known about how well older adults learn new concepts and what factors best promote learning novel categories. One factor that may affect category learning abilities is an individual’s state of mind. A number of studies demonstrate the effects of sleep, stress, affect, and motivation on cognition, …