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Phantom Limb Pain: It’S Not ‘All In My Mind, It’S In My Neurons!', Meredith Conroy (Class Of 2017)
Phantom Limb Pain: It’S Not ‘All In My Mind, It’S In My Neurons!', Meredith Conroy (Class Of 2017)
Biology Undergraduate Publications
Phantom limb pain (PLP) is a burning, stabbing, shooting, aching, and/or throbbing pain that an amputee feels in his or her amputated limb. According to recent statistics, PLP affects 50-80% of amputees—over one million amputees in the United States alone. With this condition being so widespread and detrimental to patients’ day to day life it is important to understand its mechanisms. However, there is a great deal of debate as to whether PLP is neurological or psychological.
Immunotherapy Against Drugs Of Abuse, Gianna Raimondi (Class Of 2017)
Immunotherapy Against Drugs Of Abuse, Gianna Raimondi (Class Of 2017)
Writing Across the Curriculum
Current treatments for drug addiction involve classical pharmacological therapy, involving the use of competitive or noncompetitive agonists (full, partial, or inverse) and antagonists. Drugs of abuse enter the brain after crossing the blood-brain barrier rapidly and binding to the proper receptor(s). They are able to do so because they are small and lipid soluble, and produce reinforcing effects by increasing levels of dopamine in brain areas associated with reward. This occurs in specific systems associated with addiction. In the mesolimbic system, neuron cell bodies originate in the ventral tegmental area (VTA) and project to the nucleus accumbens (NAc), amygdala, hippocampus, …