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Administration Of 5-Ht-1b Agonist Ameliorates Pseudodementia Induced By Depression In Rats, Asia Afzal, Saara Ahmad, Faiza Agha, Zehra Batool, Saiqa Tabassum, Laraib Liaquat, Sadia Sadir, Amber Nawaz, Saida Haider
Administration Of 5-Ht-1b Agonist Ameliorates Pseudodementia Induced By Depression In Rats, Asia Afzal, Saara Ahmad, Faiza Agha, Zehra Batool, Saiqa Tabassum, Laraib Liaquat, Sadia Sadir, Amber Nawaz, Saida Haider
Department of Biological & Biomedical Sciences
Major depressive disorder (MDD) is the leading cause of memory impairment in general population. The serotonin hypothesis provides a target model for the treatment of depression and depression-associated memory loss. 5-HT-1B receptor is suggested as a potential candidate in the pathophysiology of depressive illness. Dysfunction of 5-HT-1B receptors has been observed previously in depressive patients. Zolmitriptan, 5-HT-1B agonist is clinically recommended for the treatment of migraine. However, in present study this drug was tested as a potential treatment for depression and associated memory loss by altering the serotonergic function at receptor level. Rats (n=24) were equally divided into unstressed and …