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The G Protein-Coupled Serotonin 1a Receptor Augments Protein Kinase C Ε -Mediated Neurogenesis In Neonatal Mouse Hippocampus—Pkc Ε -Mediated Signaling In The Early Hippocampus, Sreyashi Samaddar, Sudarshana Purkayastha, Souleymane Diallo, Subramanyam J. Tantry, Ryan Schroder, Pranavan Chanthrakumar, Michael J. Flory, Probal Banerjee
The G Protein-Coupled Serotonin 1a Receptor Augments Protein Kinase C Ε -Mediated Neurogenesis In Neonatal Mouse Hippocampus—Pkc Ε -Mediated Signaling In The Early Hippocampus, Sreyashi Samaddar, Sudarshana Purkayastha, Souleymane Diallo, Subramanyam J. Tantry, Ryan Schroder, Pranavan Chanthrakumar, Michael J. Flory, Probal Banerjee
Publications and Research
The neurotransmitter serotonin (5-HT) plays an important role in mood disorders. It has been demonstrated that 5-HT signaling through 5-HT1A receptors (5-HT1A-R) is crucial for early postnatal hippocampal development and later-life behavior. Although this suggests that 5-HT1A-R signaling regulates early brain development, the mechanistic underpinnings of this process have remained unclear. Here we show that stimulation of the 5-HT1A-R at postnatal day 6 (P6) by intrahippocampal infusion of the agonist 8-OH-DPAT (D) causes signaling through protein kinase Cε (PKCε) and extracellular receptor activated kinase ½ (ERK1/2) to boost neuroblast proliferation in the dentate gyrus (DG), as displayed by an increase …
Tributyltin Inhibits Neural Induction Of Human Induced Pluripotent Stem Cells, Shigeru Yamada, Yusuke Kubo, Daiju Yamazaki, Yuko Sekino, Yoko Nomura, Sachiko Yoshida, Yusunari Kanda
Tributyltin Inhibits Neural Induction Of Human Induced Pluripotent Stem Cells, Shigeru Yamada, Yusuke Kubo, Daiju Yamazaki, Yuko Sekino, Yoko Nomura, Sachiko Yoshida, Yusunari Kanda
Publications and Research
Tributyltin (TBT), one of the organotin compounds, is a well-known environmental pollutant. In our recent study, we reported that TBT induces mitochondrial dysfunction, in human-induced pluripotent stem cells (iPSCs) through the degradation of mitofusin1 (Mfn1), which is a mitochondrial fusion factor. However, the effect of TBT toxicity on the developmental process of iPSCs was not clear. The present study examined the effect of TBT on the differentiation of iPSCs into the ectodermal, mesodermal, and endodermal germ layers. We found that exposure to nanomolar concentration of TBT (50 nM) selectively inhibited the induction of iPSCs into the ectoderm, which is the …
Prevention Of Dendritic And Synaptic Deficits And Cognitive Impairment With A Neurotrophic Compound, Narjes Baazaoui, Khalid Iqbal
Prevention Of Dendritic And Synaptic Deficits And Cognitive Impairment With A Neurotrophic Compound, Narjes Baazaoui, Khalid Iqbal
Publications and Research
Background: The use of neurotrophic factors to treat Alzheimer’s disease (AD) is hindered by their blood–brain barrier impermeability, short half-life, and severe side effects. Peptide 021 (P021) is a neurotrophic/neurogenic tetrapeptide that was derived from the most active region of the ciliary neurotrophic factor (CNTF) by epitope mapping. Admantylated glycine was added to its C-terminal to increase its blood–brain barrier permeability and decrease its degradation by exopeptidases to make it druggable. Here, we report on the preventive effect of P021 in 3 × Tg-AD, a transgenic mouse model of AD.
Methods: P021 was administered in the diet at 3 months, …