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Application Of Genomic Technologies To Study Infertility, Nicholas Rui Yuan Ho
Application Of Genomic Technologies To Study Infertility, Nicholas Rui Yuan Ho
Arts & Sciences Electronic Theses and Dissertations
An estimated one in eight couples in the United States are diagnosed with infertility. There is a significant genetic contribution to infertility, with estimates of heritability ranging from 0.2 to 0.5. We know surprisingly little about the genetic causes, with only slightly more than a hundred genes known to cause human infertility. I have been translating recent advances in genomics to study infertility in a more efficient manner, in order to improve our knowledge of the genetic causes. By using high throughput genomics and proteomics datasets from other groups, I was able to feed that into a machine learning algorithm …
A Novel Ultrashort Pulsed Laser Method For Pathogen Inactivation, Shaw-Wei David Tsen
A Novel Ultrashort Pulsed Laser Method For Pathogen Inactivation, Shaw-Wei David Tsen
Arts & Sciences Electronic Theses and Dissertations
Emerging viral pathogens represent a constant and prominent threat to human health worldwide. There is a dire need to develop new pathogen inactivation techniques that can be used to safeguard the blood supply and to generate inactivated vaccines against these emerging viruses. Unfortunately, current techniques are inadequate because they introduce toxic/carcinogenic chemicals or alter the structure of the products, leading to loss of safety and efficacy. We have developed a novel, chemical-free ultrashort pulsed laser treatment system capable of inactivating a broad spectrum of both enveloped and non-enveloped viruses. We found that ultrashort pulsed laser treatment targets the vibrational modes …