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Wayne State University Dissertations
Chondrogenesis, Inflammation, NF-kB, Reactive oxygen species, Transgelin, Vascular disease
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Identifying Sm22 As A Key Player In Arterial Diseases, Jianbin Shen
Identifying Sm22 As A Key Player In Arterial Diseases, Jianbin Shen
Wayne State University Dissertations
Background : Expression of vascular smooth muscle cell (VSMC) cytoskeleton markers including SM22 is down-regulated in arterial diseases including atherosclerosis where inflammation and osteochondrogenesis are present. However, the role of this downregulation in arterial pathogenesis is unknown. Hypothesis : Downregulation of SM22 may actively contribute to arterial pathogenesis. Methods : Five Sm22 knockout (Sm22-/-) mice and their wild type littermates were subjected to carotid artery denudation, an artery injury model. Analyses were conducted on carotid arteries 2 weeks after injury. Primary VSMCs were isolated from mouse aortas and investigated individually at passage 2 to 4. Sm22 knockdown was …