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Fluorescent reporter; Granulomas; Lung; Macrophages; Mycobacterium tuberculosis; Polymerase chain reaction; Tuberculosis
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Understanding The Role Of A Hemerythrin-Like Protein In Mycobacterium Tumerculosis, Caitlyn Herndon
Understanding The Role Of A Hemerythrin-Like Protein In Mycobacterium Tumerculosis, Caitlyn Herndon
HIM 1990-2015
According to the Centers for Disease Control and Prevention (CDC), 8 million people each year are infected with Mycobacterium tuberculosis (Mtb) leading to 1.5 million deaths annually. This staggering number calls for advancements in understanding this bacterium so progress can be made in treating and preventing the disease. It is particularly important to understand mechanisms by which TB survives inside hostile host immune cells known as macrophages and within hypoxic granuloma lesions of the lung. Preliminary microarray data has shown that a TB gene known as Rv2633c is induced upon macrophage invasion. Bioinformatic analysis of Rv2633c coding sequence shows the …