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Molecular Regulators Of Post-Golgi Vldl Transport Vesicle (Pg-Vtv) Biogenesis, Aladdin Riad
Molecular Regulators Of Post-Golgi Vldl Transport Vesicle (Pg-Vtv) Biogenesis, Aladdin Riad
Electronic Theses and Dissertations
Amongst its numerous functions, the liver is responsible for the synthesis and secretion of very low-density lipoprotein (VLDL). VLDL particles play the important role of facilitating the transport of lipids within the aqueous environment of the plasma; yet high plasma concentrations of these particles result in the pathogenesis of atherosclerosis, while low VLDL secretion from the liver results in hepatic steatosis. VLDL synthesis in the hepatocyte is completed in the Golgi apparatus, which serves as the final site of VLDL maturation prior to its secretion to the bloodstream. The mechanism by which VLDL’s targeted transport to the plasma membrane is …
Identification Of Proteins Regulating Vldl Sorting Into The Vldl Transport Vesicle (Vtv) And Involved In The Biogenesis Of The Vtv, Samata Tiwari
Identification Of Proteins Regulating Vldl Sorting Into The Vldl Transport Vesicle (Vtv) And Involved In The Biogenesis Of The Vtv, Samata Tiwari
Electronic Theses and Dissertations
Increased secretion of very low-density lipoprotein (VLDL), a triglyceride-rich lipoprotein, by the liver causes hypertriglyceridemia, which is a major risk factor for the development of atherosclerosis. The rate of VLDL-secretion from the liver is determined by its controlled transport from the endoplasmic reticulum (ER) to the Golgi. The ER-to-Golgi transport of newly synthesized VLDL is a complex multi-step process and is mediated by the VLDL transport vesicle (VTV). Once a nascent VLDL particle is synthesized in the lumen of the ER, it triggers the process of VTV-biogenesis and this process requires coat complex II (COPII) proteins that mediate the formation …