Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Drug resistance in microorganisms (2)
- Eukaryotic cells (2)
- Mobile genetic elements (2)
- Mycobacteria (2)
- Transposons (2)
-
- Tuberculosis (2)
- Antibiotic resistance (1)
- Antibiotics (1)
- Antibody (1)
- Asymmetric cell division (1)
- Bacteria (1)
- Biofilms (1)
- Cell cycle (1)
- Cellular control mechanisms (1)
- Cellular signal transduction (1)
- Central carbon metabolism (1)
- Centrosomes (1)
- Cyclic adenylic acid (1)
- Cyclic nucleotide phosphodiesterases (1)
- Cyclic-AMP signaling (1)
- Dental plaque (1)
- Genetic recombination (1)
- Growth factors (1)
- HelR (1)
- Immunity (1)
- Immunization (1)
- Immunoglobulin A (1)
- Introns (1)
- LTR retrotransposon (1)
- Lactococcus lactis (1)
Articles 1 - 7 of 7
Full-Text Articles in Entire DC Network
Elucidating The Relationship Between Recombination Frequency And Antibiotic Resistance In Staphylococcus Aureus, Joseph R. Matthews
Elucidating The Relationship Between Recombination Frequency And Antibiotic Resistance In Staphylococcus Aureus, Joseph R. Matthews
Legacy Theses & Dissertations (2009 - 2024)
Staphylococcus aureus is a common commensal and opportunistic pathogen of humans. It causes a variety of diseases, ranging from skin and soft infections to life-threatening invasive diseases. Many strains of S. aureus have developed resistance to a variety of antibiotic classes, including many beta-lactams. The evolution and dissemination of antibiotic resistance in S. aureus lay in large part to its remarkable ability of acquiring DNA from other organisms through horizontal gene transfer and recombination. In this study, I elucidated the relationship between frequencies of recombination events and horizontally acquired antibiotic resistant genes in a population of S. aureus sampled from …
Isolating Oral Bacterial Species From A Single Donor Through A Multi-Step Detection Method, Khalid Al-Lakhen
Isolating Oral Bacterial Species From A Single Donor Through A Multi-Step Detection Method, Khalid Al-Lakhen
Legacy Theses & Dissertations (2009 - 2024)
The human oral microbiome is one of the most complex microbiome communities in the human body and its role in maintaining health is not fully understood. Previous research shows that the transition from health to disease is accompanied by changes in community abundance and structure. To fully understand the symbiotic relationship formed between bacterial species that leads to the formation of a functional healthy biofilm structure, we must study the various structural relationships and subsequent molecular interactions among individual species within the biofilm. In this thesis, I have isolated a pure bacteria species from a single donor's dental plaque and …
Characterization Of A Putative Helicase In Rifampicin Resistance Of Mycobacterium Abscessus:, Aavrati Saxena
Characterization Of A Putative Helicase In Rifampicin Resistance Of Mycobacterium Abscessus:, Aavrati Saxena
Legacy Theses & Dissertations (2009 - 2024)
Mycobacterium abscessus (Mab), a non-tuberculous environmental mycobacterium is one of the emerging pathogens. The number of Mab infections has doubled in the past decade. It is also an opportunistic pathogen usually infecting immunocompromised individuals and causing numerous skin and soft tissue infections. It commonly causes lung infections in people who are already infected with one or other lung infections such as tuberculosis. The treatment of Mab infections is difficult because of its intrinsic resistance to most of the antibiotics available. This project studies Rifampicin (RIF) resistance in Mab, as RIF is a well-established treatment for other mycobacterial infections including tuberculosis, …
Host Factors Affecting Group Ii Intron Retrotransposition, Justin Michael Waldern
Host Factors Affecting Group Ii Intron Retrotransposition, Justin Michael Waldern
Legacy Theses & Dissertations (2009 - 2024)
Group II introns are self-splicing mobile elements that are thought to be the evolutionary ancestors of eukaryotic retrotransposons, the spliceosome, and spliceosomal introns. Yet, little is known about how group II introns have coevolved within their native hosts or about the corresponding host biology.Using the Ll.LtrB intron in its native host, Lactococcus lactis, I first sought to identify host factors that influence retrotransposition. Since retrotransposition can be costly to the host organism, group II introns must achieve a delicate balance between self-proliferation and host preservation. By utilizing the native host organism, my goal was to unearth retrotransposition-related mechanisms that have …
The Phosphodiesterase, Rv0805, Is An Unheralded Component Of Tb Complex Mycobacterial Physiology In And Beyond Camp Homeostasis, James R. Mcdowell
The Phosphodiesterase, Rv0805, Is An Unheralded Component Of Tb Complex Mycobacterial Physiology In And Beyond Camp Homeostasis, James R. Mcdowell
Legacy Theses & Dissertations (2009 - 2024)
Phosphodiesterases (PDEs) are integral components of 3’,5’-cyclic adenosine monophosphate (cAMP) signaling pathways by degrading cAMP to modulate the concentration, duration, and localization of the cAMP signal which maintains the specificity of cAMP pathways. The human pathogen, Mycobacterium tuberculosis (Mtb) has a unique cAMP network architecture with at least 15 adenylyl cyclases (ACs) that generate cAMP, but only one characterized PDE, Rv0805, which is found exclusively in pathogenic mycobacteria. Rv0805 can influence Mtb cAMP levels but the absence of Rv0805 orthologs in non-pathogenic mycobacteria and apparent separation of Rv0805 from cAMP directed roles led to numerous questions surrounding PDE function in …
Retrotransposon-Mediated Transduction Of An Environmental Cue To Regulate Centrosome Fate, Shawn Patrick Murphy
Retrotransposon-Mediated Transduction Of An Environmental Cue To Regulate Centrosome Fate, Shawn Patrick Murphy
Legacy Theses & Dissertations (2009 - 2024)
In 1969, the enrichment of mobile element repeat sequences led Britton and Davidson to propose the hypothesis that gene expression in higher eukaryotes is regulated through the exaptation of mobile elements. In this work, I have explored the hypothesis that mobile elements can also be harnessed by the host to regulate asymmetric cell division, thereby determining cell fate. Retrotransposons are ubiquitous eukaryotic mobile elements that transpose through an RNA intermediate. They are often active in cell types that divide asymmetrically to yield daughter cells with different fates, such as embryonic stem cells, germline stem cells, neuronal stem cells and the …
Passive Immunization Against Invasive Salmonella Enterica, Angelene Richards
Passive Immunization Against Invasive Salmonella Enterica, Angelene Richards
Legacy Theses & Dissertations (2009 - 2024)
The Gram-negative bacterium, Salmonella enterica is a prominent etiologic agent of both diarrheal disease and enteric fever that encompasses over 2500 serovars, including S. Typhimurium (STm) and S. Typhi (STy). S. enterica is transmitted through contaminated food and water and, following ingestion, invades the gastrointestinal (GI) mucosa. The bacterium uses flagellar-based motility to target microfold (M) cells overlying gut-associated lymphoid tissues known as Peyer’s patches in the small intestine. Entry into Peyer’s patch tissues is a pivotal step in the infection process, as the bacterium can then disseminate systemically in the host. Given the rise in antibiotic resistance amongst S. …