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The Role Of Follicular Dendritic Cells In Human Immunodeficiency Virus Pathogenesis, Sonya Lynn Heath
The Role Of Follicular Dendritic Cells In Human Immunodeficiency Virus Pathogenesis, Sonya Lynn Heath
Theses and Dissertations
Infection with Human Immunodeficiency Virus-1(HIV) results in a disease process characterized by three stages: an acute phase characterized by viremia, a clinically latent stage with little or no detection of virus in the blood, and the last stage, AIDS, which. is characterized. by marked immunodeficiency. During clinical latency, CD4+ T cells decline over a period lasting from a few to several years. Throughout this period, HIV is found trapped on the surface of follicular dendritic cells(FDC) in the germinal centers of secondary lymphoid tissues and this is the primary site of active viral replication. We hypothesize that FDC, and the …