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Neuronal Correlates For Neuroendocrine Habituation To Repeated Stress, Sara Matovic
Neuronal Correlates For Neuroendocrine Habituation To Repeated Stress, Sara Matovic
Electronic Thesis and Dissertation Repository
One way that the body actively responds to an impending stressor is by increasing systemic glucocorticoids through the activation of the hypothalamic-pituitary-adrenal (HPA) axis. While it is essential for short-term adaptation to stress, the sustained activation of the HPA axis during chronic stress can be detrimental and is linked to stress-related psychiatric conditions such as anxiety and depression. Therefore, it is important that the HPA axis adapts, or habituates, during chronic stress to minimize the negative consequences. Corticotropin releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (PVN) function to assimilate incoming information from the stress circuitry and …
The Stress Process Model For Community-Dwelling Adults With Mental Disorders, Samantha Davie
The Stress Process Model For Community-Dwelling Adults With Mental Disorders, Samantha Davie
Electronic Thesis and Dissertation Repository
Background: Although stress has been linked to poor mental health outcomes for various populations, less is known about the impact of stress on individuals already diagnosed with mental disorders. Objective: Explore the association between stress and general psychological distress (GPD), using the stress process model. Design: Data were collected in 2011 from community-dwelling adults who have had at least one diagnosed mental disorder for at least one year in their lifetime (n=380), and are cross-sectional in nature. Multivariable linear regression was used to assess the association between stress and GPD, with various psychological resources, such as coping, social support, and …