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Abstracts Of Theses For Graduate Degrees
Abstracts Of Theses For Graduate Degrees
MCV/Q, Medical College of Virginia Quarterly
Medical College of Virginia, June, 1969. Summary includes: Anticholinergic Agents Based on Ariens' Dual Receptor Site Theory by Archie Jay Beebe; The Relationship Between Emotionality and Behavioral Performance in a Random Population of Male Charles River Rats by Stanley F. Bernstein; Fetal Development and Functional Significance of the Epiphysis Cerebri in Rats and Hamsters: A Light and Electron Microscopic Investigation by Jeanne W. Clabough; Separation and Partial Characterization of Components Derived from Human Erythrocyte Membranes by Roy Frederick J. Davis; Free Amino Acid Release from Isolated Rat Liver Cells by Gerald Irwin Drury; Passer Domesticus by William W. Farrar; The …
Paroxysmal Nocturnal Hemoglobinuria: New Thoughts, Wendell F. Rosse
Paroxysmal Nocturnal Hemoglobinuria: New Thoughts, Wendell F. Rosse
MCV/Q, Medical College of Virginia Quarterly
I have tried to summarize some of the facts we know, and some questions we need to ask in a disease which, although it is not common, probably is not as rare as we once thought. Once the diagnosis is made, one must be very careful in tending to the patients, since there are instances in which they react much differently than would normal people--either by the hemolytic episode or with other complications. This is especially true with regard to surgery, which may be extremely dangerous in these patients. The post-operative course may be complicated by thrombosis, infections, and other …
New Concepts In The Management Of Neonatal Jaundice: Use Of Enzyme Induction And Phototherapy, Harold M. Maurer
New Concepts In The Management Of Neonatal Jaundice: Use Of Enzyme Induction And Phototherapy, Harold M. Maurer
MCV/Q, Medical College of Virginia Quarterly
All the observations suggest that phenobarbital and light may be of therapeutic value in controlling neonatal hyperbilirubinemia. In pregnancies in which one might anticipate increased bilirubin formation by the newborn baby, the use of phenobarbital during pregnancy and in the neonatal period, and exposure of the infant to light may provide methods other than exchange transfusion to reduce the concentration of serum bilirubin in the infant. Clinical trials should proceed cautiously, however, since phenobarbital is known to stimulate the activity of liver microsomal enzymes that metabolize, steroids, hormones, and other normal body substrates. It is not known whether this effect …
Transfusion Problems In Hemolytic Anemias, Ali A. Hossaini
Transfusion Problems In Hemolytic Anemias, Ali A. Hossaini
MCV/Q, Medical College of Virginia Quarterly
In this presentation I have attempted to present some of the transfusion problems that face the Blood Bank and the physician treating the patient. I have briefly discussed methods of recognizing the complicating factors, interpretation of their clinical significance, and the proper hemotherapeutic management of such cases. Finally, I hope that this presentation is a convincing thesis for a better understanding of the Blood Bank and its problems, since the patient's welfare is better served when there is a rapport between the clinician and the Blood Bank staff.
Immune Suppression In Auto-Immune Hemolytic Anemia, John H. Moon
Immune Suppression In Auto-Immune Hemolytic Anemia, John H. Moon
MCV/Q, Medical College of Virginia Quarterly
The acquired auto-immune hemolytic anemias represent a diversity of disease states in which the most constant immunologic finding is a positive direct anti-human globulin test (van Loghem, 1965; Swisher et al, 1965). This is true of the symptomatic variety of acquired hemolytic anemia as well as the idiopathic form. The positive Coomb's test has been seen in association with primary atypical pneumonias, occasionally in favism, in some bacterial and drug induced hemolytic anemias, in patients with malignancies of the lymphoid tissues, and in collagen-vascular disorders--chiefly SLE.
New Thoughts On Hereditary Spherocytosis, Robert I. Weed
New Thoughts On Hereditary Spherocytosis, Robert I. Weed
MCV/Q, Medical College of Virginia Quarterly
In addition to its accentuated pattern of rigidity at decreasing ATP/Ca ratios, the hereditary spherocyte poses a special challenge within the splenic pulp because of its shape. In addition to the geometric requirement for deformability, the spleen also poses a challenge to HS cells because of its pH, and probably also the pO₂ within the splenic pulp. Thus, it is suggested that splenectomy is essentially curative in hereditary spherocytosis because it removes an organ with unique anatomic requirements for red cell passage as well as an adverse environment of lower pH and pO₂.
Glucose-6-Phosphate Dehydrogenase Deficiency, Daniel N. Mohler
Glucose-6-Phosphate Dehydrogenase Deficiency, Daniel N. Mohler
MCV/Q, Medical College of Virginia Quarterly
Major attention was first focused on the problem of acute hemolytic anemia in the early 1950's, during the Korean War. Large numbers of American Negroes stationed in Korea developed this anemia after taking primaquine for treatment or prophylaxis of malaria. A study group was formed in Chicago under the direction of Alving; it was this group of investigators who contributed much of the early information which has led to our understanding of this type of anemia (Dern, et al, 1954; Dern, Beutler and Alving, 1954; Beutler, Dern, and Alving, 1954). This also resulted in an upsurge of interest in red …