Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 7 of 7
Full-Text Articles in Entire DC Network
The Effect Of Mechanical Vibration On Alveolar Bone Following Experimental Periodontitis: A Time Course Study, Joshua Murphy
The Effect Of Mechanical Vibration On Alveolar Bone Following Experimental Periodontitis: A Time Course Study, Joshua Murphy
Master's Theses (2009 -)
Introduction: High-frequency vibration with low magnitude acceleration has varying effects on alveolar bone. The objectives of this study were to establish a murine model for periodontitis and to explore the best time window of this model to investigate the effects of high frequency, low magnitude mechanical vibration on alveolar bone following ligature-induced experimental periodontitis. Materials and Methods: Ninety-five 11-week-old inbred strain C57BL/67 male mice were randomly assigned into four groups: 1) healthy control (n = 9); 2) healthy + mechanical vibration (n = 8); 3) experimental periodontitis + no treatment (n=7); and 4) experimental periodontitis + vibration (n = 9). …
Tobacco Enhances Bacterial-Induced Periodontal Bone Loss In Mice., Mina Iskander
Tobacco Enhances Bacterial-Induced Periodontal Bone Loss In Mice., Mina Iskander
Electronic Theses and Dissertations
Background: Tobacco smoking is the leading environmental risk factor for periodontal diseases. Delineation of the mechanisms underlying tobacco-induced or exacerbated periodontitis is hampered by the lack of an appropriate and reliable animal model. Hypothesis: We hypothesized that Porphyromonas-gingivalis-infected, cigarette smoke-exposed mice would represent reproducible models of acute (ligature model) and chronic (oral gavage model) tobacco-enhanced periodontitis that reflect multiple aspects of the disease noted in human smokers. Methods: In a chronic oral gavage disease model, Balb/c mice (6-8 weeks, 4 groups of n = 6 per group) were exposed to smoke produced by a Teague-10 smoking machine from 1R6F research …
The Emerging Oral Pathogen, Filifactor Alocis, Disrupts Neutrophil Functions To Enhance Survival And Dysregulate Inflammation., Irina Miralda Molina
The Emerging Oral Pathogen, Filifactor Alocis, Disrupts Neutrophil Functions To Enhance Survival And Dysregulate Inflammation., Irina Miralda Molina
Electronic Theses and Dissertations
Periodontitis is an irreversible, chronic inflammatory disease where pathogenic microbial communities accumulate in the gingival crevice. Advances in culture-independent techniques have facilitated the identification of new bacterial species in periodontal lesions, such as the Gram-positive anaerobe, Filifactor alocis. Neutrophils are a major component of the innate host response, and the outcome of their interaction with F. alocis may be a determinant of oral health status. While neutrophil functions typically protect the host against periodontal disease, oral pathogens have adapted to evade or disarm neutrophil microbicidal functions while promoting mechanisms that drive inflammation, which also provides a source of nutrients …
Oral Health And Quality Of Life: A Clinic-Based Sample, Kinan M. Al-Bitar
Oral Health And Quality Of Life: A Clinic-Based Sample, Kinan M. Al-Bitar
Master's Theses (2009 -)
Attachment loss due to periodontal diseases is associated with functional limitations as well as physical pain and psychological discomfort, which may lead to a reduced quality of life. This manuscript is intended to answer the question, if periodontal status has an effect on oral health related quality of life. Survey data were collected in an U.S. dental school clinical setting from n=97 adults (54% females, average age 51 years) in a cross- sectional study. Quality of life related to oral health was assessed with the Oral Health Impact Profile (OHIP-49). Additional measures using the DMFT index, periodontal status, dental anxiety, …
Peri-Implantitis Risk Prediction Using A Computer Based Periodontal Risk Calculator Tool: A Retrospective Study, Walaa Al Zaibak
Peri-Implantitis Risk Prediction Using A Computer Based Periodontal Risk Calculator Tool: A Retrospective Study, Walaa Al Zaibak
Master's Theses (2009 -)
Introduction: Although literature is abundant on the diagnosis and management of peri-implantitis after it has occurred, to our current knowledge there are no studies that have specifically looked into the relationship between peri-implantitis and the periodontal risk assessment tool used for natural dentitions.Material and Methods: In this retrospective study, the patient population included patients (>20 years of age) who had implants placed and restored at Marquette University School of Dentistry (MUSOD) from 2008 to 2016. Further, the restored implants in these patients must have been in function for at least one year and followed up in the school …
Selenomonas Sputigena: Growth Conditions And Projected Virulence Factors Of An Emerging Oral Pathogen, Kayla A. Keller
Selenomonas Sputigena: Growth Conditions And Projected Virulence Factors Of An Emerging Oral Pathogen, Kayla A. Keller
Theses and Dissertations
Periodontal diseases are ubiquitous diseases. They can affect people through a chronic infection that happens over a lifetime, but also as an aggressive infection that afflicts the younger population. It not only results in tooth loss and a lower quality of life, but it can also lead to fatal secondary infections like cervical cancer, heart disease, and Alzheimer’s disease. This study looks at Selenomonas sputigena, an emerging oral pathogen, that has been hypothesized to contribute to periodontal disease. It has been linked to fatal septicemia and has been found in increased abundance within the oral biofilm during peak infection. …
Amixicile As A Novel Antimicrobial Treatment For Periodontitis: A Pilot Study In The Non-Human Primate, Macaca Mulatta, Denver J. Lyons
Amixicile As A Novel Antimicrobial Treatment For Periodontitis: A Pilot Study In The Non-Human Primate, Macaca Mulatta, Denver J. Lyons
Theses and Dissertations
Periodontitis is an inflammatory disease with a bacterial etiology in a susceptible host. Given the bacterial etiology, a selective antimicrobial agent with minimal side effects could be a useful adjunct to traditional therapy. Amixicile is a novel antimicrobial that targets the pyruvate: ferredoxin oxidoreductase (PFOR) which is an enzyme that is critical for anaerobic bacterial metabolism. It has been found to have no effect on commensal, aerobic microbes and has little to no side-effects thus far in animal models. In this study, two nonhuman primates of the Macaca mulatta species with naturally occurring mild chronic periodontitis were studied before and …