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Characterization And Personalization Of Botulinum Toxin Type A Therapy For Upper Limb Tremor In Parkinson Disease And Essential Tremor Patients Using Multi-Sensor Kinematic Technology, Olivia Samotus

Electronic Thesis and Dissertation Repository

Tremor commonly affects the upper extremities in essential tremor (ET) and Parkinson disease (PD) patients where many experience functional disability and ultimately seek therapy. As ET and PD tremor features overlap and clinical assessment is challenging due to its highly complex nature, misdiagnosis is common resulting in unsuitable therapies and prognosis. Current treatment options for ET and PD tremor include pharmacotherapy, focal therapy with botulinum toxin type A (BoNT-A) injections, and surgical interventions which provide modest relief of tremor. However, such therapies are commonly associated with significant adverse events and lack long-term efficacy and tolerability. Hence lack of standardized, objective …

Markerless Radiostereogammetry Of The Shoulder Joint In Humans: Comparisons Of Scapulohumeral Kinematics Between Individuals With Healthy And Supraspinatus-Impaired Shoulders, Ashley N. Hannon

Electronic Thesis and Dissertation Repository

The purpose of this collection of studies was to further develop the knowledge of shoulder motion in order to better understand joint function through direct measurement of 3D scapulohumeral joint kinematics using a technique of high accuracy. Markerless, bi-planar fluoroscopic radiostereometric analysis using a generic shoulder model was developed in this thesis, reducing the amount of radiation exposure to subjects. The studies compared kinematic data of the scapulohumeral joint in six degrees of freedom with a precise, in-vivo measuring technique. Data were collected on young and older healthy individuals, individuals with a torn supraspinatus and post-surgical intervention.

Although this generic …

The Effects Of A Hip Flexor Stretching Program On Running Kinematics In Individuals With Limited Passive Hip Extension, Jeff H. Mettler

Theses and Dissertations--Kinesiology and Health Promotion

INTRODUCTION: Tightness of the hip flexor muscle group may contribute to altered sagittal plane kinematics of the lumbo-pelvic-hip (LPH) complex during dynamic movements. Therefore, the purpose of this study is to analyze the effects of a three-week home-based stretching program on passive hip extension (PHE), as well as on active hip extension (AHE), anterior pelvic tilt (APT), and lumbar spine extension (LSE) when running. METHODS: Twenty healthy subjects with limited PHE underwent a 3D gait analysis both prior (PRE) and following (POST) a three-week static hip flexor stretching program. RESULTS: Following the stretching program, peak PHE increased significantly (P < 0.001), while no significant improvements were reported in AHE, APT, or LSE. In addition, no relationship was found between the change in PHE with either the change in AHE, APT, or LSE. Finally, a high relationship was observed between AHE and APT during running (r = 0.83, p < 0.001), and low relationships were observed between APT and LSE (r = -0.41, p = 0.08) and AHE and LSE (r = -0.34, p = 0.15). CONCLUSION: A three-week static stretching program of the hip flexor musculature resulted in an increase in PHE, but the sagittal plane kinematics of the LPH complex during running remained unchanged. The correlations observed between AHE, APT, and LSE suggest there is a kinematic relationship between the hip, pelvis, and spine.