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Novel Splenic Antigen-Presenting Cells Derive From A Lin-C-Kitlo Progenitor, Pravin Periasamy, Jonathan Tan, Helen O'Neill
Novel Splenic Antigen-Presenting Cells Derive From A Lin-C-Kitlo Progenitor, Pravin Periasamy, Jonathan Tan, Helen O'Neill
Helen O'Neill
No abstract provided.
Adjuvant Concurrent Chemoradiation Using Intensity-Modulated Radiotherapy And Simultaneous Integrated Boost For Resected High-Risk Adenocarcinoma Of The Distal Esophagus And Gastro-Esophageal Junction., Brian Yaremko, David Palma, Abigail Erickson, Gregory Pierce, Richard Malthaner, Richard Inculet, Rashid Dar, George Rodrigues, Edward Yu
Adjuvant Concurrent Chemoradiation Using Intensity-Modulated Radiotherapy And Simultaneous Integrated Boost For Resected High-Risk Adenocarcinoma Of The Distal Esophagus And Gastro-Esophageal Junction., Brian Yaremko, David Palma, Abigail Erickson, Gregory Pierce, Richard Malthaner, Richard Inculet, Rashid Dar, George Rodrigues, Edward Yu
Richard A. Malthaner
Purpose: Multimodality therapy leads to improved outcomes for adenocarcinoma of the distal esophagus and gastroesophageal junction (GEJ) over surgery alone. At our institution, adjuvant chemoradiation (chemoRT) using IMRT and SIB is standard of care for resected high-risk disease. In this study, we review our experience with a recent cohort of patients treated in this manner. Methods and materials: We identified 18 patients with resected T3 and/or N1 adenocarcinoma of the distal esophagus and GEJ who received adjuvant chemoRT. A large elective volume (PTV1) and a smaller high-risk volume (PTV2) were irradiated simultaneously using IMRT and an SIB technique. All patients …
Adjuvant Concurrent Chemoradiation Using Intensity-Modulated Radiotherapy And Simultaneous Integrated Boost For Resected High-Risk Adenocarcinoma Of The Distal Esophagus And Gastro-Esophageal Junction., Brian Yaremko, David Palma, Abigail Erickson, Gregory Pierce, Richard Malthaner, Richard Inculet, Rashid Dar, George Rodrigues, Edward Yu
Adjuvant Concurrent Chemoradiation Using Intensity-Modulated Radiotherapy And Simultaneous Integrated Boost For Resected High-Risk Adenocarcinoma Of The Distal Esophagus And Gastro-Esophageal Junction., Brian Yaremko, David Palma, Abigail Erickson, Gregory Pierce, Richard Malthaner, Richard Inculet, Rashid Dar, George Rodrigues, Edward Yu
Richard A. Malthaner
Purpose: Multimodality therapy leads to improved outcomes for adenocarcinoma of the distal esophagus and gastroesophageal junction (GEJ) over surgery alone. At our institution, adjuvant chemoradiation (chemoRT) using IMRT and SIB is standard of care for resected high-risk disease. In this study, we review our experience with a recent cohort of patients treated in this manner. Methods and materials: We identified 18 patients with resected T3 and/or N1 adenocarcinoma of the distal esophagus and GEJ who received adjuvant chemoRT. A large elective volume (PTV1) and a smaller high-risk volume (PTV2) were irradiated simultaneously using IMRT and an SIB technique. All patients …
Cultural Immersion – What Impact Does It Have?, Janie Smith, S Springer, B Murphy, C Wolfe, J Togno, Katrina Bramstedt, Sally Sargeant
Cultural Immersion – What Impact Does It Have?, Janie Smith, S Springer, B Murphy, C Wolfe, J Togno, Katrina Bramstedt, Sally Sargeant
Sally Sargeant
No abstract provided.
Assessment Of Medical Students’ Learning Outcomes In Australia : Current Practice, Future Possibilities, David Wilkinson, Benedict Canny, Jacob Pearce, Hamish Coates, Daniel Edwards
Assessment Of Medical Students’ Learning Outcomes In Australia : Current Practice, Future Possibilities, David Wilkinson, Benedict Canny, Jacob Pearce, Hamish Coates, Daniel Edwards
Dr Jacob Pearce
All 19 medical schools in Australia examine and assess the performance of their students, but do so largely in isolation from each other. That is, most schools design, develop and deliver their own exams, against their own curriculum and standards, and students pass, fail and are graded with little external moderation or comparison. Accreditation of schools by the Australian Medical Council (AMC) provides some reassurance that assessment practices are appropriate in medical schools. However, very limited data are available for benchmarking performance against any national standard, or between medical schools in Australia. The Australian Medical Assessment Collaboration has been designed …
Same Admissions Tools, Different Outcomes : A Critical Perspective On Predictive Validity In Three Undergraduate Medical Schools, Daniel Edwards, Tim Friedman, Jacob Pearce
Same Admissions Tools, Different Outcomes : A Critical Perspective On Predictive Validity In Three Undergraduate Medical Schools, Daniel Edwards, Tim Friedman, Jacob Pearce
Dr Jacob Pearce
Admission to medical school is one of the most highly competitive entry points in higher education. Considerable investment is made by universities to develop selection processes that aim to identify the most appropriate candidates for their medical programs. This paper explores data from three undergraduate medical schools to offer a critical perspective of predictive validity in medical admissions. This study examined 650 undergraduate medical students from three Australian universities as they progressed through the initial years of medical school (accounting for approximately 25 per cent of all commencing undergraduate medical students in Australia in 2006 and 2007). Admissions criteria (aptitude …
Same Admissions Tools, Different Outcomes : A Critical Perspective On Predictive Validity In Three Undergraduate Medical Schools, Daniel Edwards, Tim Friedman, Jacob Pearce
Same Admissions Tools, Different Outcomes : A Critical Perspective On Predictive Validity In Three Undergraduate Medical Schools, Daniel Edwards, Tim Friedman, Jacob Pearce
Dr Tim Friedman
Admission to medical school is one of the most highly competitive entry points in higher education. Considerable investment is made by universities to develop selection processes that aim to identify the most appropriate candidates for their medical programs. This paper explores data from three undergraduate medical schools to offer a critical perspective of predictive validity in medical admissions. This study examined 650 undergraduate medical students from three Australian universities as they progressed through the initial years of medical school (accounting for approximately 25 per cent of all commencing undergraduate medical students in Australia in 2006 and 2007). Admissions criteria (aptitude …
Concepts Of Illness Among The Swahili Of Lamu, Kenya, Rebecca Gearhart, Munib Abdulrehman
Concepts Of Illness Among The Swahili Of Lamu, Kenya, Rebecca Gearhart, Munib Abdulrehman
Rebecca Gearhart
The Public Health Pbrn Program: A Summative Report, Glen P. Mays
The Public Health Pbrn Program: A Summative Report, Glen P. Mays
Glen Mays
This report provides a six-year summary of the work of the Public Health Practice-Based Research Networks Program, supported by the Robert Wood Johnson Foundation.
Simulation And Optimization Modeling For Drive-Through Mass Vaccination – A Generalized Approach, Aman Gupta, Gerald W. Evans, Sunderesh S. Heragu
Simulation And Optimization Modeling For Drive-Through Mass Vaccination – A Generalized Approach, Aman Gupta, Gerald W. Evans, Sunderesh S. Heragu
Aman Gupta
Proper planning and execution of mass vaccination at the onset of a pandemic outbreak is important for local health departments. Mass vaccination clinics are required to be setup and run for naturally occurring pandemic outbreaks or even in response to terrorist attacks, e.g., anthrax attack. Walk-in clinics have often been used to administer vaccines. When a large percentage of a population must be vaccinated to mitigate the ill-effects of an attack or pandemic, drive-through clinics appear to be more effective because a much higher throughput can be achieved when compared to walk-in clinics. There are other benefits as well. For …
Socioeconomic-Status And Mental Health In A Personality Disorder Sample: The Importance Of Neighborhood Factors, Zach Walsh, M. Tracie Shea, Shirley Yen, Emily B. Ansell, Carlos M. Grilo, Thomas H. Mcglashan, Robert L. Stout, Donna S. Bender, Andrew E. Skodol, Charles A. Sanislow, Leslie C. Morey, John G. Gunderson
Socioeconomic-Status And Mental Health In A Personality Disorder Sample: The Importance Of Neighborhood Factors, Zach Walsh, M. Tracie Shea, Shirley Yen, Emily B. Ansell, Carlos M. Grilo, Thomas H. Mcglashan, Robert L. Stout, Donna S. Bender, Andrew E. Skodol, Charles A. Sanislow, Leslie C. Morey, John G. Gunderson
Charles A. Sanislow, Ph.D.
This cross-sectional study examined the associations between neighborhood-level socioeconomic-status (NSES), and psychosocial functioning and personality pathology among 335 adults drawn from the Collaborative Longitudinal Personality Disorders Study. Participants belonged to four personality disorder (PD) diagnostic groups: Avoidant, Borderline, Schizotypal, and Obsessive Compulsive. Global functioning, social adjustment, and PD symptoms were assessed following a minimum two-year period of residential stability. Residence in higher-risk neighborhoods was associated with more PD symptoms and lower levels of functioning and social adjustment. These relationships were consistent after controlling for individual-level socioeconomic-status and ethnicity; however, the positive association between neighborhood-level socio-economic risk and PD symptoms was …
Authoring Simulations For High Stakes Student Evaluation, Janet Willhaus, Gail Burleson, Janice Palaganas, Pamela Jeffries
Authoring Simulations For High Stakes Student Evaluation, Janet Willhaus, Gail Burleson, Janice Palaganas, Pamela Jeffries
Janet Willhaus
Although simulation methods have primarily been used for teaching in nursing education, there is a growing interest in the use of simulation for student and program evaluation. Developing simulation scenarios for high stakes evaluation differs from traditional teaching/learning scenario authorship in a number of ways. This manuscript describes the process used to write, pilot test, and revise scenarios used in the National League for Nursing High Stakes Testing feasibility study. Observations and reported differences in scenario development and facilitation may provide insight to others regarding the best use of summative simulation scenarios.
Design Of An Enterprise Architecture For Electronic Patient Care Record (Epcr) Information Exchange In Ems, Ben Schooley, Neset Hikmet
Design Of An Enterprise Architecture For Electronic Patient Care Record (Epcr) Information Exchange In Ems, Ben Schooley, Neset Hikmet
Neset Hikmet
EMS is an organized and collaborative effort between several organizations providing different levels or tiers of care designed to transport sick or injured patients to the hospital. Significant challenges to efficient, accurate, and integrated inter-organizational information exchange exist for communicating pre-hospital patient information to hospital emergency departments. The goal of this research was to investigate the requirements and design of a business process-oriented inter-organizational enterprise architecture from a multi-stakeholder perspective. This paper describes an action-design research effort aimed at improving information exchange across pre-hospital and hospital organizations in the Santa Clara County, CA Health and Hospital System. In this paper, …
Antimicrobial Peptide Coating Of Dental Implants: Biocompatibility Assessment Of Recombinant Human Beta Defensin-2 For Human Cells, Patrick Warnke, Eske Voss, Paul Russo, Sebastien Stephens, Michael Kleine, Hendrik Terheyden, Qin Liu
Antimicrobial Peptide Coating Of Dental Implants: Biocompatibility Assessment Of Recombinant Human Beta Defensin-2 For Human Cells, Patrick Warnke, Eske Voss, Paul Russo, Sebastien Stephens, Michael Kleine, Hendrik Terheyden, Qin Liu
Qin Liu
Purpose: Artificial materials such as dental implants are at risk of bacterial contamination in the oral cavity. Human beta defensins (HBDs), small cationic antimicrobial peptides that exert a broad-spectrum antibacterial function at epithelial surfaces and within some mesenchymal tissues, could probably help to reduce such contamination. HBDs also have protective immunomodulatory effects and have been reported to promote bone remodeling. The aim of this study, therefore, was to investigate the influence of recombinant HBD-2 on the proliferation and survival of cells in culture.
Materials and Methods: Human mesenchymal stem cells (hMSCs), human osteoblasts, human keratinocytes (control), and the HeLa cancer …
Rhea Paul Elected Vp Of International Association For The Study Of Child Language, Rhea Paul
Rhea Paul Elected Vp Of International Association For The Study Of Child Language, Rhea Paul
Rhea Paul
No abstract provided.
Protect Your Health On A Sport Travel Tour, Franki Burke
Protect Your Health On A Sport Travel Tour, Franki Burke
Franki Burke
No abstract provided.
Addressing The Persistence Of Tuberculosis Among The Canadian Inuit Population: The Need For A Social Determinants Of Health Framework, Kassandra C. Kulmann Ma Candidate, Chantelle Am Richmond Professor
Addressing The Persistence Of Tuberculosis Among The Canadian Inuit Population: The Need For A Social Determinants Of Health Framework, Kassandra C. Kulmann Ma Candidate, Chantelle Am Richmond Professor
Chantelle Richmond
Canadian Aboriginal people have poorer levels of health than the general population. A serious issue is the high rate of tuberculosis (TB) among the Inuit population; rates are much higher than those of the general Canadian population. Several social determinants of health (SDOH), including household crowding and poverty, are strongly correlated with TB prevalence. In this paper, we describe the medical and social determinants of TB, and critically examine the TB literature specific to the Inuit population. The majority of studies recommend biomedical interventions for the treatment of TB. Few researchers have employed the social determinants of health theory to …
The Quest For Full Text: An In-Depth Examination Of Pubget For Medical Searchers, Robin Featherstone, Denise Hersey
The Quest For Full Text: An In-Depth Examination Of Pubget For Medical Searchers, Robin Featherstone, Denise Hersey
Denise Hersey
This article examines Pubget, a free Web-based search engine for life sciences researchers for conducting searches of the medical literature and retrieving full-text PDFs. Its search functionality and add-on features are evaluated to determine potential for library instruction and promotion. With many libraries relying on OpenURL link resolvers to connect searchers with institutional subscriptions, Pubget offers an alternative by combining search, article-level link resolving, and authentication in a single platform. The authors determine advantages and disadvantages for using Pubget based on product testing and make recommendations for institutions interested in “activating” subscriptions in Pubget.
Pharmacist Empathy In Smoking Cessation Counseling, Caleb Lyman, Megan Mcnicol, Maria Miller, Yevgeniy Solokha, Kelly J. Wright, Aleda M.H. Chen
Pharmacist Empathy In Smoking Cessation Counseling, Caleb Lyman, Megan Mcnicol, Maria Miller, Yevgeniy Solokha, Kelly J. Wright, Aleda M.H. Chen
Kelly J. Wright, R.Ph., Pharm.D.
Cigarette smoking and nicotine addiction are prevalent in today’s society. Approximately 19% of American adults (43.8 million people) smoke cigarettes. Smoking is associated with health risks such as Chronic Obstructive Pulmonary Disease (COPD), infertility, low birth weight, respiratory symptoms, heart disease, and lung cancer and is responsible for roughly $96 billion in health care costs. Provider empathy has been proven effective in other treatments like cold and cancer; however, its effectiveness in smoking cessation has not yet been studied. Empathy is defined in two realms: cognitive and affective. In the cognitive domain, individuals have the ability to understand and view …
5 Steps To Emotionally Recovering From A Car Crash, Denver Burke
5 Steps To Emotionally Recovering From A Car Crash, Denver Burke
Denver Burke
A car accident can be a life changing event which creates many problems for a person, both physically and mentally. This post helps review certain things to help alleviate the pain for a more satisfied, more productive mentality.
The Concomitant Relationship Shared By Sleep Disturbances And Type 2 Diabetes: Developing Telemedicine As A Viable Treatment Option, Pennie S. Seibert, Jennifer Valerio, Codieann Dehaas
The Concomitant Relationship Shared By Sleep Disturbances And Type 2 Diabetes: Developing Telemedicine As A Viable Treatment Option, Pennie S. Seibert, Jennifer Valerio, Codieann Dehaas
Pennie S. Seibert
Individually, sleep disturbances and type 2 diabetes pose pervasive challenges to health. In addition, the negative symptomology associated with each condition is exacerbated further when presenting concomitantly. This relationship formulates a destructive loop wherein those with diabetes experience decreased sleep quality, which, in turn, worsens a wide range of health threats experienced by those with diabetes, including obesity and glucose intolerance. Because major lifestyle changes and daily care are needed to effectively manage both diabetes and sleep disturbances, an efficient and timely modality of treatment is essential. Advanced technology incorporating telemedicine and telehealth has the potential to enhance treatment by …
Definition Of An Hla-Dpw2-Restricted Epitope On Ns3, Recognized By A Dengue Virus Serotype-Cross-Reactive Human Cd4+ Cd8- Cytotoxic T-Cell Clone, Ichiro Kurane, Li Chen Dai, Peter G. Livingston, Elaine Reed, Francis A. Ennis
Definition Of An Hla-Dpw2-Restricted Epitope On Ns3, Recognized By A Dengue Virus Serotype-Cross-Reactive Human Cd4+ Cd8- Cytotoxic T-Cell Clone, Ichiro Kurane, Li Chen Dai, Peter G. Livingston, Elaine Reed, Francis A. Ennis
Li Dai
We previously reported that the clone JK34 was cross-reactive for dengue virus types 1, 2, 3, and 4 and recognized NS3 (I. Kurane, M. A. Brinton, A. L. Samson, and F. A. Ennis, J. Virol. 65:1823-1828, 1991). In the present experiments, we defined the epitope at the amino acid level, with 93 15-mer overlapping peptides which cover the entire NS3. A peptide 4 which contains amino acids 251 to 265 of NS3 sensitized the autologous B lymphoblastoid cell line (LCL) to the lysis by JK34. The smallest peptide recognized by JK34 was a 10-mer peptide which contains amino acids 255 …
Mutation Of Human Immunodeficiency Virus Type 1 At Amino Acid 585 On Gp41 Results In Loss Of Killing By Cd8+ A24-Restricted Cytotoxic T Lymphocytes, Li Chen Dai, Kim West, Rebecca A. Littaua, Kazuo Takahashi, Francis A. Ennis
Mutation Of Human Immunodeficiency Virus Type 1 At Amino Acid 585 On Gp41 Results In Loss Of Killing By Cd8+ A24-Restricted Cytotoxic T Lymphocytes, Li Chen Dai, Kim West, Rebecca A. Littaua, Kazuo Takahashi, Francis A. Ennis
Li Dai
A human leukocyte antigen A24-restricted CD8+ cytotoxic T-cell clone specific for gp41 of human immunodeficiency virus type 1 was isolated from an infected individual. The epitope was localized to amino acids 584 to 591 (YLKDQQLL, NL43 env sequence) of gp41 by using a panel of recombinant vaccinia viruses that contain truncated env genes and synthetic peptides. The clone killed autologous B-lymphoblastoid cell lines pulsed with a synthetic peptide reflecting the sequence of the IIIB and MN strains. This clone, however, failed to kill target cells pulsed with the peptides that have a mutation from Lys to Arg or Gln at …
Linda Strong Appointed President Of Connecticut Association Of Public Health Nurses, Linda L. Strong
Linda Strong Appointed President Of Connecticut Association Of Public Health Nurses, Linda L. Strong
Linda L. Strong
No abstract provided.
Comparison Of In Vitro Biocompatibility Of Nanobone(®) And Biooss(®) For Human Osteoblasts, Qin Liu, Timothy Douglas, Christiane Zamponi, Stephan Becker, Eugene Sherry, Sureshan Sivananthan, Frauke Warnke, Jörg Wiltfang, Patrick Warnke
Comparison Of In Vitro Biocompatibility Of Nanobone(®) And Biooss(®) For Human Osteoblasts, Qin Liu, Timothy Douglas, Christiane Zamponi, Stephan Becker, Eugene Sherry, Sureshan Sivananthan, Frauke Warnke, Jörg Wiltfang, Patrick Warnke
Qin Liu
Introduction:Scaffolds for bone tissue engineering seeded with the patient's own cells might be used as a preferable method to repair bone defects in the future. With the emerging new technologies of nanostructure design, new synthetic biomaterials are appearing on the market. Such scaffolds must be tested in vitro for their biocompatibility before clinical application. However, the choice between a natural or a synthetic biomaterial might be challenging for the doctor and the patient. In this study, we compared the biocompatibility of a synthetic bone substitute, NanoBone®, to the widely used natural bovine bone replacement material BioOss®.Material and methods: The in …
Nanospiderwebs: Artificial 3d Extracellular Matrix From Nanofibers By Novel Clinical Grade Electrospinning For Stem Cell Delivery, Mohammad Alamein, Qin Liu, Sebastien Stephens, Stuart Skabo, Frauke Warnke, Robert Bourke, Peter Heiner, Patrick Warnke
Nanospiderwebs: Artificial 3d Extracellular Matrix From Nanofibers By Novel Clinical Grade Electrospinning For Stem Cell Delivery, Mohammad Alamein, Qin Liu, Sebastien Stephens, Stuart Skabo, Frauke Warnke, Robert Bourke, Peter Heiner, Patrick Warnke
Qin Liu
Novel clinical grade electrospinning methods could provide three-dimensional (3D) nanostructured biomaterials comprising of synthetic or natural biopolymer nanofibers. Such advanced materials could potentially mimic the natural extracellular matrix (ECM) accurately and may provide superior niche-like spaces on the subcellular scale for optimal stem-cell attachment and individual cell homing in regenerative therapies. The goal of this study was to design several novel “nanofibrous extracellular matrices” (NF-ECMs) with a natural mesh-like 3D architecture through a unique needle-free multi-jet electrospinning method in highly controlled manner to comply with good manufacturing practices (GMP) for the production of advanced healthcare materials for regenerative medicine, and …
Ceramic Scaffolds Produced By Computer-Assisted 3d Printing And Sintering: Characterization And Biocompatibility Investigations, Patrick Warnke, Hermann Seitz, Stephan Becker, Sureshan Sivananthan, Eugene Sherry, Qin Liu, Jorge Wiltfang, Timothy Douglas
Ceramic Scaffolds Produced By Computer-Assisted 3d Printing And Sintering: Characterization And Biocompatibility Investigations, Patrick Warnke, Hermann Seitz, Stephan Becker, Sureshan Sivananthan, Eugene Sherry, Qin Liu, Jorge Wiltfang, Timothy Douglas
Qin Liu
Hydroxyapatite (HAP) and tricalcium phosphate (TCP) are two very common ceramic materials for bone replacement. However, in general HAP and TCP scaffolds are not tailored to the exact dimensions of the defect site and are mainly used as granules or beads. Some scaffolds are available as ordinary blocks, but cannot be customized for individual perfect fit. Using computer-assisted 3D printing, an emerging rapid prototyping technique, individual three-dimensional ceramic scaffolds can be built up from TCP or HAP powder layer by layer with subsequent sintering. These scaffolds have precise dimensions and highly defined and regular internal characteristics such as pore size. …
A Clinically-Feasible Protocol For Using Human Platelet Lysate And Mesenchymal Stem Cells In Regenerative Therapies, Patrick Warnke, Andreas Humpe, Dirk Strunk, Sebastien Stephens, Frauke Warnke, Jorge Wiltfang, Katharina Schallmoser, Mohammad Alamein, Robert Bourke, Peter Heiner, Qin Liu
A Clinically-Feasible Protocol For Using Human Platelet Lysate And Mesenchymal Stem Cells In Regenerative Therapies, Patrick Warnke, Andreas Humpe, Dirk Strunk, Sebastien Stephens, Frauke Warnke, Jorge Wiltfang, Katharina Schallmoser, Mohammad Alamein, Robert Bourke, Peter Heiner, Qin Liu
Qin Liu
The transplantation of human stem cells seeded on biomaterials holds promise for many clinical applications in cranio-maxillo-facial tissue engineering and regenerative medicine. However, stem cell propagation necessary to produce sufficient cell numbers currently utilizes fetal calf serum (FCS) as a growth supplement which may subsequently transmit animal pathogens. Human platelet lysate (HPL) could potentially be utilized to produce clinical-grade stem cell-loaded biomaterials as an appropriate FCS substitute that is in line with clinically-applicable practice. The goal of this study was to investigate whether HPL can be successfully used to propagate human mesenchymal stem cells (HMSCs) seeded on clinically-approved collagen materials …
Mass Production Of Nanofibrous Extracellular Matrix With Controlled 3d Morphology For Large-Scale Soft-Tissue Regeneration, Mohammad Alamein, Sebastien Stephens, Qin Liu, Stuart Skabo, Patrick Warnke
Mass Production Of Nanofibrous Extracellular Matrix With Controlled 3d Morphology For Large-Scale Soft-Tissue Regeneration, Mohammad Alamein, Sebastien Stephens, Qin Liu, Stuart Skabo, Patrick Warnke
Qin Liu
Aim: Biomaterials that mimic the nanofibrous architecture of the natural extracellular matrix (ECM) are in the focus for stem cell hosting or delivery in tissue engineering of multilayered soft tissues such as skin, mucosa, or retina. Synthetic nanofibers for such ECM are usually produced by single-syringe electrospinning with only one needle-jet at very low production rates of 0.005–0.008 g·min−1. The aim of this study was to utilize a novel industrial needle-free multijet electrospinning device with the potential for mass production of nanofibrous ECM (NF-ECM) exhibiting a controlled three-dimensional (3D) morphology for large-scale applications such as large area skin regeneration in …
The Primordium Of A Biological Joint Replacement: Coupling Of Two Stem Cell Pathways In Biphasic Ultrasound Compressed Gel Niches, Mariea Brady, Sureshan Sivananthan, Vivek Mudera, Qin Liu, Joerg Wiltfang, Patrick Warnke
The Primordium Of A Biological Joint Replacement: Coupling Of Two Stem Cell Pathways In Biphasic Ultrasound Compressed Gel Niches, Mariea Brady, Sureshan Sivananthan, Vivek Mudera, Qin Liu, Joerg Wiltfang, Patrick Warnke
Qin Liu
The impaired temporomandibular joint might be the first to benefit from applied tissue engineering techniques because it is small and tissue growth in larger amounts is challenging. Bone and cartilage require different competing environmental conditions to be cultivated in vitro. But coupling both the osteogenic and cartilaginous pathways of mesenchymal stem cell differentiation in homeostasis will be a key essential to grow osteochondral constructs or even the first biological joint replacement in the future.
The aim of this study was to test a single source biomaterial and a single source cell type to engineer a biphasic osteochondral construct in vitro …