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Metabolic Acidosis And Respiratory Compensation In Uremia During Hemodialysis, Robert D. Gilbert

Yale Medicine Thesis Digital Library

[From the Introduction] In chronic renal insufficiency one of the products of metabolism which accumulates in the body is the hydrogen ion. The phosphoric, sulfuric, and organic acids usually eliminated in the urine accumulate. The respiratory system can and does decrease the hydrogen ion content of the body by decreasing the amount of carbonic acid present. The accumulating hydrogen ions also react with various bases throughout the body. The net result of metabolic production, respiratory elimination, and body buffering is reflected in the blood as chronic, partially compensated, metabolic acidosis. As expected the carbonic acid and block buffer concentrations are …