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Association Of Common Il-10 Promoter Gene Variants With The Susceptibility To Head And Neck Cancer In Tunisia, Lamia Makni, Cherif Ben Hamda, Abrar Al Ansari, Oussema Souaiai, Ezzedine Gazouani, Amel Mezlini, Wassim Y. Almawi, Besma Yacoubi-Loueslati
Association Of Common Il-10 Promoter Gene Variants With The Susceptibility To Head And Neck Cancer In Tunisia, Lamia Makni, Cherif Ben Hamda, Abrar Al Ansari, Oussema Souaiai, Ezzedine Gazouani, Amel Mezlini, Wassim Y. Almawi, Besma Yacoubi-Loueslati
Turkish Journal of Medical Sciences
Background/aim: We investigated the association of three IL-10 promoter single-nucleotide polymorphisms and altered IL-10 plasma levels with the risk of head and neck cancer (HNC). Materials and methods: Study subjects comprised 194 HNC patients [137 nasopharyngeal cancer (NPC) and 57 laryngeal cancer (LC)], and 263 healthy controls. Genotyping of rs1800896 (-1082A>G), rs1800871 (-819C>T), and rs1800872 (-592A>C) IL-10 variants was performed by real-time PCR; IL-10 levels were measured by enzyme amplified immuno sensitivity assay (EAISA). Results: Carriage of rs1800896 A/A genotype was more frequent in the HNC and NPC cases, but was less frequent in the controls than …