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Multilevel Factors Affecting Covid-19 Vaccination Among African American Communities In South Carolina, Ran Zhang

Theses and Dissertations

Background: Persistent health disparities has led to significant public health challenges, especially for African American (AAs) communities, and have been exacerbated by the COVID-19 pandemic. Achieving high population vaccination rates are crucial to controlling the virus’ spread. However, AAs have higher rates of COVID-19 infection and mortality than Whites, yet their vaccination rates remain relatively low. The dissertation aimed to investigate the multilevel factors and mechanisms that affect AAs’ vaccination behavior. The first objective is to assess the impact of the intrapersonal level factor (i.e., perceived barriers to vaccination) on vaccination behavior. The second objective is to investigate the impact …

Associations Between The Use Of Ssri Medication In Older Adults And Cognitive Decline And Impairment, Paige Jones

Theses and Dissertations

Previous research has indicated that depression is a risk factor for dementia. Since SSRI medication is the most common treatment for depression, it is important to determine if SSRIs are associated with reduced dementia and better cognitive outcomes. Using longitudinal data from the 2004-2014 waves of the Health and Retirement Study merged with the 2005 Prescription Drug Study, we examined potential associations between SSRI and TCA medication and cognitive impairment and cognitive decline. The study population consisted of 1,775 older adults who participated in the PDS in 2005. We found that SSRIs were associated with significantly higher odds of cognitive …

Internalizing Mental Health Symptoms And Nicotine Use Among Adolescents In Canada, England, And The Us From 2020-2022, Emily E. Hackworth

Theses and Dissertations

Background: There is a well-established bi-directional relationship between cigarette smoking and internalizing mental health (IMH) symptoms (e.g., symptoms of depression, symptoms of anxiety). However, it is unclear whether IMH symptoms are associated with using different types of nicotine products among adolescents, as adolescents are using a variety of nicotine products, including combustible products (cigarettes), non-combustible products (e-cigarettes), or combinations of both types of products. This dissertation examines associations between IMH symptoms and current use of various types of nicotine products across three countries from 2020-2022.

Methods: Data come from the 2020-2022 waves of the International Tobacco Control (ITC) Adolescents Tobacco …

Examining The Association Between Maternal Mobile Device Use, Mother-To-Infant Attachment And Infant Negative Affectivity, Imteyaz Eljarrah

Theses and Dissertations

Background: With the exponential growth in the development of technology (i.e., mobile phones, laptops, tablets) use worldwide, researchers have classified "problematic mobile device use" to encompass "addiction" or dependency on the device that distracts one from their surroundings. This distraction can be common during parenting and could negatively impact how parents interact or attach to their children. The main purpose of this study is to examine correlations between problematic mobile device use in mothers, maternal attachment to infants, and infant negativity.Methods: A cross-sectional, correlational design with a convenience sample of mothers with infants (n = 250) from five areas in …

The Effect Of Vaping On Measures Of Vocal Function In Adults: A Comparative Study, Blake Taylor Howard

Theses and Dissertations

E-cigarettes or “vapes” have become more frequently used than conventional cigarettesamong youth and young adults in the U.S., however the existing research on these products and their impact on health is limited due to its modernity. The purpose of this study was to investigate the effects of various vape products on perceptual and instrumental objective measures of voice compared to a control group of nonsmokers in a sex and age-matched sample. As vapes have rapidly evolved, more substances have become available for consumers, thus a comparison was made to differentiate the effects of two common substances used in these products, …

Associations Between Coping Style And Perceptions Of Web-Delivered Physical Activity Messages Among Women In Midlife With Cardiovascular Health Risks, Kristen Pasko

Theses and Dissertations

Midlife women are at unique risk for cardiovascular disease (CVD) and benefit from increasing physical activity (PA). Many PA interventions involve social support, though fail to address related processes such as social comparison. Desire for specific types of social support and comparison may represent emotion-focused versus problem-solving coping, though little is known about women’s preferences for/responses to these coping opportunities. The present study examined women’s selections of PA content in a digital environment. Over 7 days, women in midlife ≥1 CVD risk factor (N = 60, MAge = 50.70, SD = 5.89) wore a PA monitor and visited a proprietary …

The Inflammatory Exposome Of Major Depressive Disorder In An Egyptian Sample, Reem Deif

Theses and Dissertations

Major depressive disorder (MDD) has been recognized as a global public health concern affect-ing the lives of 264 million people with increasing prevalence worldwide. Inspired by the expo-somic research, this study aims to investigate the dynamic and complex interplay between dif-ferent demographic, lifestyle, environmental factors and bimolecular factors that are potentially involved in the pathology of MDD in a sample of Egyptian adults living in Cairo. This is in an attempt to acknowledge the biological underpinnings of MDD without underestimating the role of environmental influences. The context of Egypt provides richness to the current study given the national transition from …

Validation Of Harmonized Cognitive Assessment Protocol (Hcap) In Egypt: A Sub Study Of The Egyptian Longitudinal Study Of Aging (Al-Seha), Sara Ayman Moustafa

Theses and Dissertations

Abstract Building upon the insights gained from the AL-SEHA pilot study, which underscored the pressing need for comprehensive cognitive assessment tools in Egypt, a subsequent research initiative was launched. This initiative sought to address the escalating burden of dementia and Alzheimer's Disease Related Dementias (ADRD) by adapting and validating the Harmonized Cognitive Assessment Protocol (HCAP) for the Egyptian context. The validation study, conducted with 300 participants aged 55 and over, drawn from diverse backgrounds and healthcare settings in Cairo, Mansoura, and Beni Suef, demonstrated the HCAP's effectiveness across different age and education levels within the Egyptian population. The tool exhibited …

From Crisis To Aftermath: The Role Of Nursing Professional Development Educators During The Covid-19 Pandemic: A Realist Case Study, Kimberly Kanner

Theses and Dissertations

The purpose of this qualitative, realistic inquiry case study was to examine and understand the experiences of NPD educators as they assisted new graduate nurses transitioning into clinical nursing practice during the COVID-19 pandemic in acute care hospitals in the state of New York. Moreover, this research study sought to understand how the COVID-19 pandemic brought about changes to the NPD educator's role and their ability to assist new graduate nurses transitioning into clinical practice post-pandemic. The sample included NPD educators from acute care hospitals in the state of New York. Data collection included semi-structured interviews and document collection. The …

"I Can Just Be Myself And Part Of That Is Being A Vaper." A Qualitative Analysis Of Vaping Identity, Megan Wahl

Theses and Dissertations

Introduction: E-cigarette use among young adults (18-24 years-old) is becoming increasingly problematic. Current vaping cessation programs draw from existing tobacco interventions which focus on reducing nicotine consumption. Vaping, however, is distinctly different from smoking. Rooted in sociology, recent research has evaluated social identity as a new way of addressing complex health behaviors. Purpose: Young adulthood is a unique time for experimenting with multiple identities. Understanding social identity formation around vaping may have public health utility in addressing current e-cigarette use. To date there is limited research about vaping identity and the process by which it is formed among young adults …

Technology Acceptance Model (Tam)-Based Predictors Of Internet-Accessed Testing For Sexually Transmitted Infections Among Young Adults In The United States Using An Online Sample, Immaculate Apchemengich

Theses and Dissertations

Sexually Transmitted Infections (STIs) continue to be a global public health concern, with an estimated 357 million new infections of curable STIs each year. As of 2018, there were more than 2.4 million cases of STIs in the United States (US) with youth being affected disproportionately. Whereas STIs generally affect youth disproportionately compared to other age groups, young adults (18-24) have a heightened risk for STIs.There is a plethora of research on access to STI testing using conventional modes, but less research exists on access to testing services via the Internet (e-STI services). With only conventional modes of testing, national …

Examining Time Spent On Social Media And Its Effects On Mental Health In Terms Of Body Image Concerns, Self Esteem And Overall Quality Of Life Among U.S. Adults, Rigel Macarena Pinon

Theses and Dissertations

Daily exposure and dependence on computer-based technologies (smartphones) allows for 24/7 constant access to social media (i.e., Facebook, Instagram, Twitter, YouTube, TikTok, and other sites) and has empirically shown to have a positive and negative impact on the mental health of individuals across cultures in our society. Depending on user intent, exposure, and interests, social media platforms can create a sense of community; however, some of the platforms and what users post about themselves has led to cyberbullying, low self-esteem, user addiction, suicide, self-harm behaviors such as eating disorders, sexual dysfunction, and other mental health issues such as depression and …

Employee Commitment In Nursing Facilities, Robert Frediani

Theses and Dissertations

This research is meant to help employers improve employee retention, especially in the nursing facility healthcare market in the United States. This quantitative correlational study investigates the relationship between employees' intent to stay or leave their jobs and the commitment they hold for their organization. It also explores the correlation between employee commitment and moderating factors in the workplace. The aim for this study is to improve understanding about how an employee’s intention to quit or stay in their job correlates with the strength and type of commitment they have to their job and organization. The research, guided by six …

Examining Lung Cancer Disparities And Risk Factors In Wisconsin, Usa (2016-2020), Mathew Chidera Ugwuanyi

Theses and Dissertations

Studies over the United States has shown that disparity still exists in lung cancer mortality. Such disparity has been attributed to several risk factors such as genetics, socio-economic status, comorbidities, amongst others. This study investigates the spatial variations in lung cancer mortality rates in Wisconsin, USA, through analyzing county-level data from the Center for Disease Control (CDC) and National Cancer Institute’s Surveillance, Epidemiology and End Results (SEER). Emphasis is placed on exploring the relationship between access to lung cancer services, socio-economic factors, and lung cancer mortality rate, utilizing American Community Survey and County ranking data. Scan Statistics (SaTScan) was used …

Mri Image Regression Cnn For Bone Marrow Lesion Volume Prediction, Kevin Yanagisawa

Theses and Dissertations

Bone marrow lesions (BMLs), occurs from fluid build up in the soft tissues inside your bone. This can be seen on magnetic resonance imaging (MRI) scans and is characterized by excess water signals in the bone marrow space. This disease is commonly caused by osteoarthritis (OA), a degenerative join disease where tissues within the joint breakdown over time [1]. These BMLs are an emerging target for OA, as they are commonly related to pain and worsening of the diseased area until surgical intervention is required [2]–[4]. In order to assess the BMLs, MRIs were utilized as input into a regression …

Practice Patterns And Medical Provider Perceptions Of Ketamine In The Treatment Of Psychiatric Disorders: A Nationwide Survey, Amna M. Aslam

Theses and Dissertations

Background: Major Depressive Disorder (MDD) significantly impacts society, with a prevalence of 8.4% in the U.S., highlighting the need for effective treatments for treatment-resistant depression (TRD). Ketamine, while not FDA-approved for TRD, shows promise in treating mental health disorders and is used in specialized clinics, though evidence of effectiveness is scarce. Objectives: This study investigates the use of off-label ketamine for TRD and other disorders, focusing on ketamine clinic operations where the drug is administered, treatment methods, patient characteristics, and ketamine's impact on psychiatric care, from providers' perspectives. Methods: The survey was distributed to over 1,000 ketamine providers across the …

Assessing Providers’ Readiness To Integrate Mat Services In A Primary Care Setting, Carmen Ingram-Thorpe

Theses and Dissertations

Opioid use disorder is a growing concern in the United States. Despite medication-assisted treatment (MAT) being a more effective treatment option than behavioral treatment alone, primary care providers’ rate of adoption and utilization of MAT has not matched the demand of the opioid crisis. The largest barrier facing our local community is the availability of organizations and providers that can and will actually provide MAT services. The purpose of this study was to identify factors that impact primary care providers’ readiness to treat individuals with opioid use disorder (OUD) using MAT. This study used the ADKAR model as framework, which …

Mental Health Help-Seeking Behaviors And Service Utilization Of Black College Students, Troy J. Keys

Theses and Dissertations

Black college students are less likely to seek mental health services compared to other students. While previous research has identified barriers and facilitators contributing to Black college students’ help-seeking behaviors, the current political and social climate and pandemic have negatively impacted their mental health thus warranting the exploration of these factors again. This study aimed to identify the mental health help-seeking behaviors and attitudes of Black college students, the barriers and supports for help-seeking behaviors, their preferred service utilization providers, and their thoughts about promoting mental health help-seeking among their peers. Black college students (n = 21) enrolled at an …

Frozen By Worry And Fatigue? A Mixed Methods Approach To Understanding The Lived Experiences Of Freezing Of Gait, Sarah M. Ghose

Theses and Dissertations

This study utilized a mixed methods emergent, phenomenological approach to (1) understanding the lived experience of freezing of gait for individuals diagnosed with Parkinson’s Disease and (2) determining the role of anxiety and sleep in freezing of gait outcomes. Participants included 13 adults diagnosed with Parkinson’s Disease (N=14 for qualitative data, N=13 for quantitative data; 23.1% female-identifying, 76.9% male-identifying) who were predominantly white (92.3%) with an average age of 69 years (SD = 6.73 years). Data collection consisted of semi-structured interviews, self-report measures, actigraphic sleep data, and salivary alpha amylase biomarker collection. Results are organized into …

Variability In Perceptions Of Complementary Health Approaches Among Graduate Student Trainees, Delaney C. Bilodeau

Theses and Dissertations

Complementary Health Approaches (CHAs) encompass a diverse range of practices which are often used both independently and alongside conventional medical treatments. Understanding how graduate students training in different fields perceive CHAs is important because these professional trainees will go on to occupy roles as healthcare practitioners, researchers, policy makers, and consumers. This study used sequential rank agreement methods (Ekstrøm, Gerds, & Jensen, 2019) to investigate variations in perceptions of CHAs in a sample of graduate students (N = 416) from 140 possible training programs. Ratings of CHA familiarity, perceptions of CHA legitimacy, and willingness to recommend CHAs were compared …

The Influence Of Flavor On The Abuse Liability Of A Heated Tobacco Product And Its Feasibility As A Menthol Cigarette Substitute, Augustus White

Theses and Dissertations

Heated Tobacco Products (HTPs) purport to expose people that use cigarettes to fewer of the harmful or potentially harmful constituents of tobacco while still delivering reinforcing amounts of nicotine (Auer, Concha-Lozano et al., 2017). An exemplar of the HTP class, IQOS, and its three varieties of “HeatSticks” have been authorized by the Food and Drug Administration (FDA) as “Modified Risk Tobacco Products” (MRTP). However, as the FDA is planning to ban menthol as a characterizing flavor in cigarettes, questions remain regarding whether characterizing flavors should be permitted in HTPs (FDA, 2022e). New evidence regarding HTP abuse liability (i.e., the likelihood …

The Effect Of Experienced Compassion At Work On Nursing Home Certified Nursing Assistants' Well-Being And Turnover Intentions, Kristin M. Macdonald

Theses and Dissertations

Statement of problem and objectives: Could experienced compassion at work alleviate nursing home certified nursing assistant (CNA) burnout? This study investigates whether experienced compassion at work predicts higher well-being (meaningfulness of work, psychological vitality, and resilience) for CNAs, and if well-being predicts lower turnover intentions.

Procedure followed: This is a prospective, observational, survey-based study with three timepoint data collection. Convenience sampling of Kansas and Virginia NHs was conducted (n=13). All CNAs working at the NHs were study eligible. CNAs received gift cards with laddered incentives for ongoing participation. There was in-person administration of a CNA survey at each timepoint. …

My Secret Struggle: Starving, Purging, And Numbing My Emotions. An Autoethnographic Analysis Of My Lifelong Battle With Anxiety, Depression, And Eating Disorders, Hasmek G. Siwajian

Theses and Dissertations

Adolescent females and young adult women between the ages of 12 and 25 are at a higher risk of engaging in self-destructive and life-threatening behaviors linked to anxiety, depression, and eating disorders when they do not have access to suitable treatment options or coping mechanisms (Garcia et al., 2020). This study highlights the heightened vulnerability of adolescent females and young adult women aged 12 to 25 who engage in self-destructive behaviors associated with anxiety, depression, and eating disorders when adequate treatment options or coping mechanisms are lacking. Through an autoethnographic approach, the researcher delves into her daily struggles and breakthroughs …

Exploring The Impact Of The Covid-19 Pandemic On Adolescent Mental Health: An Integrative Systematic Review, Ruth Maouda

Theses and Dissertations

An integrative systematic review was conducted to understand the potential impact of the COVID-19 pandemic on adolescent mental health and to identify what contributing risk and protective factors increased or decreased the likelihood that these mental health outcomes were experienced among adolescents, including those from diverse and vulnerable communities. Furthermore, this review examined interventions and coping strategies identified within the literature that were beneficial in mitigating these harmful pandemic-related effects. Methods. Data was collected from five electronic databases and included peer-reviewed, English-language articles published between 2020-present in the United States, comprised of adolescent participants aged 11-19. All studies were required …

Associations Between Childhood Trauma And Tobacco Dependence Among Latine Adults: Testing The Protective Effects Of Compassion For Self And Others, Camila Tirado

Theses and Dissertations

Tobacco dependence has posed a significant public health challenge in the United States and disproportionately affects Latine adults' risk of developing a variety of adverse health conditions. Childhood trauma is a recognized risk factor for dependence, overall health, and mental health concerns. Still, the influence of compassion for self or compassion for others in this context remains unclear. This cross-sectional study investigated the moderating effects of self-compassion and compassion for others on the relationship between childhood trauma and cigarette dependence among Latine adults. Data was collected through questionnaires assessing childhood trauma, self-compassion, cultural values and factors, compassion for others, and …

Drugging The Histone Acetyltransferase Ep300 Modulates Alternative Splicing At Schizophrenia Risk Genes, Shravani Malay

Theses and Dissertations

Purpose. We will evaluate the effects of drugging the epigenetic histone acetyltransferase (HAT) enzyme p300, encoded by the schizophrenia risk gene EP300, on genome-wide gene expression in neural cells. We hypothesize that drugging p300 will affect gene expression and alternative splicing of other schizophrenia risk genes. Our motivation is to identify potential new epigenetic treatment avenues for schizophrenia.

Methods. Prior to my joining the lab, an experiment was conducted using the novel p300 HAT inhibitor, A-485, to modulate genomic regulation in a neural cell line (SH-SY5Y). SH-SY5Y cells were exposed to 10μM of A-485 or vehicle (DMSO) for 24 …

Social Networks As Predictors Of Musculoskeletal Injury In U.S. Army Soldiers (Snap-Mski), Kristen L. Zosel

Theses and Dissertations

INTRODUCTION: Musculoskeletal injuries (MSKIs) are the leading cause of medical non-readiness among U.S. Army Soldiers, costing the Military Health System an estimated $4.7 billion annually in direct and indirect costs. Current MSKI mitigation efforts focus on individual attributes such as body mass index and gender. However, emerging research highlights the significance of social ties on health outcomes and behaviors. This study examined the patterns of MSKI within military social networks and how social interactions, along with health behaviors such as sleep, physical activity (PA), and diet, co-occur in Soldiers with and without MSKI. METHODS: Phase 1 involved a cross-sectional sociocentric …