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Intrinsic Programmed Death Ligand 1 (Pd-L1) Role In Promoting Triple Negative Breast Cancer (Tnbc) Progression, Duaa Salem Alkaabi
Intrinsic Programmed Death Ligand 1 (Pd-L1) Role In Promoting Triple Negative Breast Cancer (Tnbc) Progression, Duaa Salem Alkaabi
Theses
This thesis is concerned with Triple Negative Breast Cancer (TNBC), which is characterized by lack of estrogen, progesterone, and HER2 receptors expression, making targeted drugs ineffective. TNBC has a high proliferative rate, which results in a poor prognosis. Chemotherapy, the primary treatment for metastatic breast cancer, is not an ideal choice due to its toxicity towards normal cells. Therefore, Cancer-targeted therapy has been developed to improve the specificity and strength of the immune system against cancer cells. PD-L1 is an immunosuppressive protein that inactivates T cells by binding to the inhibitory receptor PD-1. The clinical use of PD-L1 blockade agents …
Mechanistic Insights On The Role Of Ambrisentan, An Endothelin Type-A Receptor Antagonist, In Breast Cancer, Ruba Saleem Lutfi Amer
Mechanistic Insights On The Role Of Ambrisentan, An Endothelin Type-A Receptor Antagonist, In Breast Cancer, Ruba Saleem Lutfi Amer
Theses
The activation of the endothelin receptor type A (ETAR) by its ligand endothelin-1 (ET-1) is well known for its role in vasoconstriction. Interestingly, ET-1 and ETAR are over-expressed in various human tumours, including breast cancer. Several studies described the important role of ETAR in cancer progression and metastasis. The extensive network of interactions that exist between the ET-1 axis and other signalling pathways can trigger autocrine and paracrine signalling that modulates different tumorigenesis processes, such as cellular proliferation and survival, epithelial-to-mesenchymal transition (EMT) and chemoresistance. The main objective of this study was to investigate the antitumor effects of Ambrisentan, a …
Mechanistic Insights On The Role Of Ambrisentan, An Endothelin Type-A Receptor Antagonist, In Breast Cancer, Ruba Saleem Amer
Mechanistic Insights On The Role Of Ambrisentan, An Endothelin Type-A Receptor Antagonist, In Breast Cancer, Ruba Saleem Amer
Theses
The activation of the endothelin receptor type A (ETAR) by its ligand endothelin-1 (ET-1) is well known for its role in vasoconstriction. Interestingly, ET-1 and ETAR are over-expressed in various human tumors, including breast cancer. Several studies described an important role for ETAR in cancer progression and metastasis. The extensive network of interactions that exist between ET-1 axis and other signaling pathways can trigger an autocrine and paracrine signaling that modulates different tumorigenesis processes, such as cellular proliferation and survival, epithelial-to-mesenchymal transition (EMT) and chemoresistance. The main objective of this study was to investigate the antitumor effects of Ambrisentan, a …