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Effect Of Genipin On Cisplatin- Induced Nephrotoxicity, Eglal Orner Mahgoub

Theses

Cisplatin (CSP) is a potent and widely used chemotherapeutic agent. However, clinical efficacy of CSP is compromised due to the elicitation of nephrotoxicity and ototoxicity. In this study, I have investigated the nephroprotective effects of a phytochemical – genipin (GP) isolated from gardenia flower (Gardenia jasminoides), on a murine model of cisplatin-induced nephropathy. CSP-induced renal tissue injury was characterized by elevated levels of serum blood urea nitrogen (BUN), creatinine (Cr) and cystatin-C. In addition, levels of kidney injury molecule-1 (KIM-1) were increased in the renal tissues of CSP administered animals. CSP also induced renal oxidative stress, evidenced by increased NADPH …

Role Of Epstein-Barr Virus In The Pathogenesis Of Multiple Sclerosis, Asma Hassani

Theses

Multiple sclerosis (MS) is a chronic pathology of the central nervous system, characterized by inflammation, demyelination, and neurodegeneration. The prevalence and incidence rates of MS are on the rise worldwide. What causes MS is unknown. However, it is widely accepted that MS occurs in genetically susceptible individuals exposed to certain environmental factors. Sero-epidemiological data suggest a strong association between Epstein-Barr virus (EBV) and MS. EBV is one of the commonest viruses in the human population with ~90% global seropositivity. EBV infects naïve B cells and immortalizes them. While some postmortem studies have shown EBV in MS lesions, others have failed …

Identification And Characterization Of The Anticancer Potential Of Indigenous Medicinal Plants Of The Arabian Peninsula, Sameera Omar Mohammed Saeed Balhamar

Theses

Indigenous plant species historically used for their medicinal properties are a tremendous source for bringing newer and safer drugs to the market. A concerted effort is needed to characterize their medicinal potential and identify new molecules that could be exploited in modern medicine. The current study was undertaken to study the anticancer properties of several indigenous plants that are used by the local population of the Arabian Peninsula and beyond for various medicinal purposes. Towards this end, we acquired different plant extracts from five plants, namely Boswellia sacra (BS), Cleome droserifolia (CD), Teucrium muscatensis (TM), Orchadenus arabicus (OA), and Acredocarpus …

An Exploration Of The Effectiveness Of The Use Of Communication Apps Through Mobile Devices On Children With Autism Spectrum Disorders (Asd), Miriam O Sullivan

Theses

Autism Spectrum Disorder (ASD) is a complex neurological disorder which impacts on people in three primary areas: communication skills, social skills and behaviour skills. The diagnosis of ASD continues to rise with an estimated 1 in 100 receiving diagnoses of ASD in Ireland. There are many interventions promoted on a regular basis that claim positive effects on the basis of empirical research. However, the claims made by such studies are sometimes a little at odds with the level of methodological rigour and/or sample size employed. The research available is based on small scale international studies (America, Canada and Australia); however, …

Effects Of Aspirin On Metabolic Alterations In Type 2 Diabetic Rats, Layla Ishaq Hussain Rahmatalla Amiri

Theses

Background: Increased oxidative stress, inflammatory responses and mitochondrial dysfunction have been implicated in diabetes, obesity (diabesity) and cardiovascular diseases. Type 2 diabetes is the most common metabolic disorder, characterized by insulin resistance and pancreatic islet β-cell failure. The most common complications associated with type 2 diabetes are hyperinsulinemia, hyperglycemia, hyperlipidemia/dyslipidemia, increased inflammatory and reduced insulin response. Aspirin (ASA) and other non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with the prevention of diabetes, obesity and related cardiovascular disorders. Aspirin has been used in many clinical and experimental trials for the prevention of diabetes and associated complications.

Aims and hypothesis: Since inflammation, …

Virulence Factors, Clonality, Antibiotic And Disinfectant Resistance Of Enterobacteriaceae Isolated In The Arabian Peninsula, Noora Esmaeel Al Zarooni

Theses

The emergence and rapid spread of multi-drug resistant (MDR) Enterobacteriaceae is one of the most challenging problems we currently faced. However, locally, no details on the strains causing outbreaks are available. Furthermore, globally, we still do not understand what makes certain clones capable of spreading widely while others are only confined to sporadic cases. Aim: Our aim was to characterize the virulence factors, antibiotic and disinfectant susceptibilities of local clonal and sporadic Escherichia coli and Klebsiella pneumoniae strains and to analyze the data to reveal which particular feature might be responsible for the outbreak potential of clonal isolates. Methods: Escherichia …

Computational And Experimental Determination Of The Hydrodynamics In A Stirred Unbaffled Vessel Provided With Angle-Mounted Axial Impellers, Ji Ma

Theses

In most industrial applications, stirred tanks and reactors are typically provided with baffles to improve their mixing characteristics. However, in a number of pharmaceutical production facilities unbaffled vessels are commonly used. The absence of baffles is preferred in such cases because it reduces the potential for contamination and makes cleaning the vessel between batches easier. However, the lack of baffles also has a negative impact on the system’s hydrodynamics since it often results in poor mixing of the batch, especially if the impeller is centrally placed, since the liquid in such a system is subject to a strong tangential flow, …

The Case For Health Literacy Research In Qatar: Identifying Avenues For Progress, Yasar Alani

Theses

Abstract This thesis studies the attitudes of healthcare provider and consumer groups in Qatar towards health literacy via health promotion. Using Q methodology, data from healthcare providers and consumers was analysed to determine relative attitudes towards previous and future health campaign strategies in Qatar. Consumer data was also collected to determine attitudes towards current health promotion campaigns and the perceived effectiveness of campaigns in encouraging behaviour change. The research also investigates the obstacles that prevent healthcare consumers from adopting the healthier lifestyle choices advocated by some of these campaigns. Participants were residents of Qatar.

The concept of health literacy was …

Attitudes Of Mental Health Care Professionals Toward The Provision Of Tobacco Dependence Treatment In The Transition To A Smoke-Free Mental Health Unit: An Exploratory Mixed Method Study., Jane Chambers

Theses

Smoking rates among people with a mental illness have not declined and remain a significant and preventable risk factor contributing to increased morbidity and reduced life expectancy. This study aimed to measure commitment, thus underlying attitude of mental health professionals towards provision of tobacco dependence treatment and enablers and barriers to implementing routine tobacco dependence treatment and smoke-free policy in an acute inpatient mental health setting.

A convenience sample of health professionals from an acute inpatient mental health unit were surveyed. This exploratory mixed method study included the Tobacco Treatment Commitment Scale (TTCS), smoking status, the Fagerstrom Test for Nicotine …

An Investigation Of Nurse Education Service Models In Acute Care Metropolitan Hospitals Across Australia, Carolyn Keane

Theses

The provision of continuing professional development for nurses is necessary to support the delivery of safe patient care. Nurse education departments need to function as effectively and efficiently as possible, producing measurable outcomes to justify their cost in regard to the organisation’s financial bottom line. In reviewing the literature, three recognised models of nurse education services within hospitals were identified. These are described as centralised, decentralised and combination models. All of these models have advantages and disadvantages that can affect service delivery, quality of service and cost.

The purpose of this study was to investigate the different nurse education service …

Does Temporarily Altering Visual Perception Of Limb Size Have A Modulatory Effect On Deep-Tissue Pain? A Repeated-Measures Within-Subjects Randomised Study, M Van Selm

Theses

No abstract provided.

Dna Methylation Biomarkers For Esophageal Adenocarcinoma And Precursor Disease, Melissa L. Thomas

Theses

Esophageal adenocarcinoma has one of the poorest outcomes of all solid tumors, attributable, at least in part, to lack of an early stage diagnostic test. Aberrant methylation is an early and frequent event in carcinogenesis providing an opportunity for early cancer detection. The overall aim of this thesis is to identify and validate regions of aberrant methylation as a biomarker for early detection of esophageal adenocarcinoma and the dysplastic stages of its precursor disease, Barrett’s esophagus. By using well-classified patient data and stringent, quality controlled biospecimen selection for training and validation cohorts, I found regions of diseaseassociated aberrant methylation that …

Early Life Events And Motor Development: A Longitudinal Study, Tegan Grace

Theses

Longitudinal studies are important to fully understand the processes of neurological development during gestation and how risk factors present during this time impact motor development outcomes, yet few to date have focused on this critical time period.

The purpose of this study was to identify modifiable risk factors influencing motor development during the prenatal period. Of particular interest was finding out whether these risk factors differed between the sexes.

Participants (N=2900) were from the Western Australian Pregnancy Cohort (Raine) Study. The Raine Study began in May 1989 and women were recruited between 16-20 weeks gestation (m = 18 weeks) from …

The Impact Of Peer-Led Falls Prevention Education On Community-Dwelling Older Adults: A Mixed Methods Evaluation, Linda Khong

Theses

Older adults are not optimally engaged in falls prevention strategies. Peer education may be an approach to improving engagement and uptake of falls prevention strategies by community-dwelling older adults. However, empirical research regarding this approach has been inconclusive. Accordingly, the primary aim of this research was to design a peer-led falls prevention education program and evaluate its impact on community-dwelling older adults’ beliefs, knowledge, motivation, and intention to engage in falls prevention strategies. This research was a mixed methods study conducted in two phases. Phase 1 comprised three concurrent studies. These aimed to elucidate the issues regarding falls prevention education …

The Effects Of Maturational Variation On The Performance Of Young Australian Footballers And Their Selection Into The Australian Football League's Talent Pathway, Ashley Cripps

Theses

Traditional player development pathways share a common goal, to identify and accelerate the development of talented adolescent players for senior competition. Players who gain selection into development programs gain greater access to experienced coaches, training facilities, support staff and competition. However, despite such advantages, research has shown that few players who gain initial selection into development pathways progress into professional senior competition. A major factor which potentially contributes to poor player retention in development pathways is the initial misidentification of talented athletes due to variations in biological maturity.

Earlier maturing individuals have been shown to be at a physical advantage …

Towards The Identification Of Metabolite Markers Of Nipple Pain And Inflammation In Human Milk, Erin Fee

Theses

Background: Human milk is considered the best source of nutrition for all newborns as it contains important growth, developmental and immunological factors. The WHO (2003) recommends exclusive breastfeeding for the first six months of age, with complementary breastfeeding up to two years and beyond. However, some women experience complications of the breast that lead to early cessation of breastfeeding, which can adversely affect the well being of the developing infant and her own health.

Nipple pain is the most commonly cited reason for weaning in the first week postpartum. Nipple pain is also linked to mastitis from milk stasis and …

A Case Study Of Factors Influencing Remote University Nursing Graduates And Their Decision To Work In A Remote Hospital, Sally Clark

Theses

The health of the rural population in Western Australia (WA) is predicated on equity and access to healthcare facilities with nurses being the main component of front line staff. There continues to be a nurse shortage particularly in remote regions of Australia where the poor health status of Australian Indigenous people, and an increasing ageing population are a perennial problem. The Kimberley, the setting for this study, is a remote region in the north of WA. It has a landmass of 423,517 square kilometres with a significantly low-density population compared to the total WA population. Nearly half of the Kimberley …

Evaluating The Impact Of A Falls Prevention Community Of Practice In A Residential Aged Care Organisation, Jacqueline Francis-Coad

Theses

Falls in the residential aged care (RAC) sector are a global concern with humanitarian and economic consequences. Reducing falls using a multifactorial approach involving multidisciplinary staff is recommended, but it is not clear how RAC organisations in Australia can achieve this in a resource constrained environment. One potential solution is to develop a sustainable means of addressing falls prevention from within an organisation, creating a forum for staff to share ideas, expertise and achieve goals in a community of practice (CoP). The purpose of this research was to evaluate the impact of a falls prevention CoP on falls outcomes in …

Risk Assessment And The Utility Of Ct Coronary Angiography For Coronary Artery Disease In Hiv Infection, James Nadel

Theses

Background

Human immunodeficiency virus (HIV) infection is now considered a chronic, treatable disease, although treatment is associated with increased rates of coronary artery disease (CAD). Screening of this at-risk population for CAD remains contentious. The aim of this thesis is to provide some guidance into the management of cardiovascular disease in HIV and examine the utility of screening CTCA in this population group.

Methods

We set out to disseminate our generated results via publications. The first paper was a literature review that sought to provide insight into the management of this complex population, in particular focusing on the risk assessment …