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The Potent And Selective Histamine H3 Receptor Antagonist E169 Alleviates Cognitive Deficits And Mitigates Disturbed Pi3k/Akt/Gsk-3Β Signaling Pathway In Mk801-Induced Amnesia In Mice, Sabna Tagelsir Hassan Abdalla
The Potent And Selective Histamine H3 Receptor Antagonist E169 Alleviates Cognitive Deficits And Mitigates Disturbed Pi3k/Akt/Gsk-3Β Signaling Pathway In Mk801-Induced Amnesia In Mice, Sabna Tagelsir Hassan Abdalla
Theses
The role of Histamine H3 Receptors (H3Rs) in memory and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer’s Disease (AD) is well-accepted. Therefore, the procognitive effects of acute systemic administration of H3R antagonist E169 (2.5-10 mg/kg, i.p.) on MK801- induced amnesia using the Novel Object Recognition Test (NORT) paradigm in C57BL/6J mice were evaluated. E169 (5 mg) provided a significant memory-improving effect on MK801-induced short- and long-term memory impairments in NORT. The E169 (5 mg) provided effects were comparable to those observed with the Phosphatidyl Inositol 3-Kinase (PI3K) inhibitor LY294002 and were abrogated with the …
Transcriptomics Of Learning, Pablo Iturralde
Transcriptomics Of Learning, Pablo Iturralde
Theses
Learning is a basic and important component of behavior yet we have very little empirical information about the interaction between mechanisms of learning and evolution. In our work, we are testing hypotheses about the neurogenetic mechanisms through which animal learning abilities evolve. We are able to test this directly by using experimentally evolved populations of flies, which differ in learning ability. These populations were previously evolved within the lab by creating worlds with different patterns of change following theoretically predicted effects on which enhanced learning will evolve. How has evolution acted to modulate genes and gene expression in the brain …