Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Facile Synthesis Of Diverse N-Acyl Anthranilamides And Quinazolin-4-Ones As Hmg-Coa Reductase Inhibitor Via Pd-Catalyzed Cascade Reaction, Pathan Sultan Ismail, Irfan Khan, Vivek Kumar, Ved Prakash Verma, Monika Shukla, Anupam Dhasmana, Shashi Pandey, Girdhar Pal Singh, Jaybir Singh, Shahnawaz Khan
Facile Synthesis Of Diverse N-Acyl Anthranilamides And Quinazolin-4-Ones As Hmg-Coa Reductase Inhibitor Via Pd-Catalyzed Cascade Reaction, Pathan Sultan Ismail, Irfan Khan, Vivek Kumar, Ved Prakash Verma, Monika Shukla, Anupam Dhasmana, Shashi Pandey, Girdhar Pal Singh, Jaybir Singh, Shahnawaz Khan
School of Medicine Publications and Presentations
This manuscript describes the design and synthesis of a series of diverse N-Acyl Anthranilamides and quinazolin-4-ones derivatives (3a-3n, and 4a-4d) inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. A series of N-Acyl Anthranilamides and quinazolin-4-ones derivatives (3a-3n, and 4a-4d) were synthesized and their chemical structures were confirmed by 1 H, 13C NMR and mass spectral data. Analogs were optimized using structure-based design and physical property considerations resulting in the identification of 4b and 3d, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and chronic efficacy in a vitro model.
Synthesis And Biological Evaluation Of 2,4-Diaminopyrimidine-5-Carbonitrile And N-(2-Amino-5-Cyanopyrimidin-4-Yl)Benzamide Derivatives As Egfr Inhibitors, Pathan Sultan Ismail, Irfan Khan, Vivek Kumar Kashyap, Ved Prakash Verma, Monika Shukla, Anupam Dhasmana, Shashi Pandey, Girdhar Pal Singh, Shahnawaz Khan, Jaybir Singh
Synthesis And Biological Evaluation Of 2,4-Diaminopyrimidine-5-Carbonitrile And N-(2-Amino-5-Cyanopyrimidin-4-Yl)Benzamide Derivatives As Egfr Inhibitors, Pathan Sultan Ismail, Irfan Khan, Vivek Kumar Kashyap, Ved Prakash Verma, Monika Shukla, Anupam Dhasmana, Shashi Pandey, Girdhar Pal Singh, Shahnawaz Khan, Jaybir Singh
School of Medicine Publications and Presentations
A series of 2,4-diaminopyrimidine-5-carbonitrile and N-(2-amino-5-cyanopyrimidin-4-yl) benzamide derivatives (5–14) were synthesized and their chemical structures were confirmed by 1 H, 13C NMR and mass spectral data. Anticancer activity of all the synthesized compounds were evaluated for in vitro cytotoxic activity against a panel of four human cancer cell lines i.e., human breast (MCF-7,), cervical cancer (C33A), oral (KB) and prostrate (DU-145). All the examined compounds, demonstrated potent to moderate anticancer activity. Among all the synthesized compounds, 6 and 11 were exhibited more potent activity. Docking studies for 6 and 11 into EGFR active site was carried out to investigate their …