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Prevalence Of Binary Toxin Positive Clostridium Difficile In Diarrhoeal Humans In The Absence Of Epidemic Ribotype 027, Alan M. Mcgovern, Grace O. Androga, Daniel R. Knight, Mark W. Watson, Briony Elliott, Niki F. Foster, Barbara J. Chang, Thomas V. Riley
Prevalence Of Binary Toxin Positive Clostridium Difficile In Diarrhoeal Humans In The Absence Of Epidemic Ribotype 027, Alan M. Mcgovern, Grace O. Androga, Daniel R. Knight, Mark W. Watson, Briony Elliott, Niki F. Foster, Barbara J. Chang, Thomas V. Riley
Research outputs 2014 to 2021
Virulence of Clostridium difficile is primarily attributed to the large clostridial toxins A and B while the role of binary toxin (CDT) remains unclear. The prevalence of human strains of C. difficile possessing only CDT genes (A¯B¯CDT +) is generally low (< 5 %), however, this genotype is commonly found in neonatal livestock both in Australia and elsewhere. Zoonotic transmission of C. difficile has been suggested previously. Most human diagnostic tests will not detect A¯B¯CDT + strains of C. difficile because they focus on detection of toxin A and/or B. We performed a prospective investigation into the prevalence and genetic characteristics of A¯B¯CDT + C. difficile in symptomatic humans. All glutamate dehydrogenase or …
High Prevalence Of Toxigenic Clostridium Difficile In Public Space Lawns In Western Australia, Peter Moono, Su Chen Lim, Thomas V. Riley
High Prevalence Of Toxigenic Clostridium Difficile In Public Space Lawns In Western Australia, Peter Moono, Su Chen Lim, Thomas V. Riley
Research outputs 2014 to 2021
Clostridium difficile is a well-established hospital pathogen. Recently, it has been detected increasingly in patients without hospital contact. Given this rise in community associated infections with C. difficile, we hypothesized that the environment could play an important role in transmission of spores outside the hospital. Lawn samples (311) collected in public spaces in the metropolitan area of Perth, Western Australia, from February to June 2016 were cultured for C. difficile. C. difficile was isolated from the samples by direct and enrichment culture, and characterized by standard molecular methods using toxin gene PCR and ribotyping. The overall prevalence of …