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Investigation Of The Low-Density Lipoprotein Receptor Gene And Cholesterol As A Risk Factor For Migraine, R. Curtain, R. Lea, S. Quinlan, C. Bellis, L. Tajouri, R. Hughes, J. Macmillan, L. Griffiths
Investigation Of The Low-Density Lipoprotein Receptor Gene And Cholesterol As A Risk Factor For Migraine, R. Curtain, R. Lea, S. Quinlan, C. Bellis, L. Tajouri, R. Hughes, J. Macmillan, L. Griffiths
Lotti Tajouri
The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene on chromosome 19p13.2 performing an association analysis in 244 typical migraine-affected patients, 151 suffering from migraine with aura (MA), 96 with migraine without aura (MO) and 244 unaffected controls. The populations consisted of Caucasians only, and controls were age- and sex-matched. The results showed no significant difference between groups for allele frequency distributions of the (TA)n polymorphism even after separation of the migraine-affected individuals into subgroups of MA and …
The Methylentetrahydrofolate Reductase Gene Variant (C677t) As A Risk Factor For Essential Hypertension In Caucasians, S. Heux, F. Morin, R. Lea, M. Ovcaric, L. Tajouri, L. Griffiths
The Methylentetrahydrofolate Reductase Gene Variant (C677t) As A Risk Factor For Essential Hypertension In Caucasians, S. Heux, F. Morin, R. Lea, M. Ovcaric, L. Tajouri, L. Griffiths
Lotti Tajouri
Essential hypertension (EH) is a common, multifactorial disorder likely to be influenced by multiple genes of modest effect. The methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation is functionally important, being strongly associated with reduced enzyme activity and increased plasma levels of homocysteine. Mild hyperhomocysteinemia is a known risk factor for cardiovascular disease (CVD) and hypothesised also to be involved in hypertension pathophysiology. The present study was performed to determine the prevalence of the 677T mutation in Australian Caucasian patients diagnosed with EH and to test whether the C677T variant is associated with the disorder. A case-control cohort, consisting of 250 EH …
The Role Of Adenosine-Related Genes Variants In Susceptibility To Essential Hypertension, Kirsty Wright, Lotti Tajouri, Rod Lea, Micky Ovcaric, Stephanie Heux, Fabien Morin, Wallid Bey, John Headrick, Lyn Griffiths
The Role Of Adenosine-Related Genes Variants In Susceptibility To Essential Hypertension, Kirsty Wright, Lotti Tajouri, Rod Lea, Micky Ovcaric, Stephanie Heux, Fabien Morin, Wallid Bey, John Headrick, Lyn Griffiths
Lotti Tajouri
Objective: To test markers within adenosine-related genes: A1 and A2a receptors (ADORA1, ADORA2a) and adenosine deaminase (ADA) for potential involvement in essential hypertension (EH).
Design: Case-control association study investigating gene variants for the ADORA1, ADORA2a and ADA genes.
Participants: The study used a cohort of 249 unrelated hypertensive individuals who were diagnosed with hypertension, and an age, sex and ethnically matched group of 249 normotensive controls.
Results: The association analysis indicated that both allele and genotype frequencies did not differ significantly between the case and control groups (P > 0.05) for any of the markers tested.
Conclusion: The adenosine-related gene variants …
Investigation Of An Inducible Nitric Oxide Synthase Gene (Nos2a) Polymorphism In A Multiple Sclerosis Population, Lotti Tajouri, Virginie Martin, Micky Ovcaric, Rob Curtain, Rod Lea, Peter Csurhes, Michael Pender, Lyn Griffiths
Investigation Of An Inducible Nitric Oxide Synthase Gene (Nos2a) Polymorphism In A Multiple Sclerosis Population, Lotti Tajouri, Virginie Martin, Micky Ovcaric, Rob Curtain, Rod Lea, Peter Csurhes, Michael Pender, Lyn Griffiths
Lotti Tajouri
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting most commonly the Caucasian population. Nitric oxide (NO) is a biological signaling and effector molecule and is especially important during inflammation. Inducible nitric oxide synthase (iNOS) is one of the three enzymes responsible for generating NO. It has been reported that there is an excessive production of NO in MS concordant with an increased expression of iNOS in MS lesions. This study investigated the role of a bi-allelic tetranucleotide polymorphism located in the promoter region of the human iNOS (NOS2A) gene in MS susceptibility. A …
Investigation Of A Neuronal Nitric Oxide Synthase Gene (Nos1) Polymorphism In A Multiple Sclerosis Population, Lotti Tajouri, Linda Ferreira, Micky Ovcaric, Rob Curtain, Rod Lea, Peter Csurhes, Michael Pender, Lyn Griffiths
Investigation Of A Neuronal Nitric Oxide Synthase Gene (Nos1) Polymorphism In A Multiple Sclerosis Population, Lotti Tajouri, Linda Ferreira, Micky Ovcaric, Rob Curtain, Rod Lea, Peter Csurhes, Michael Pender, Lyn Griffiths
Lotti Tajouri
Multiple Sclerosis (MS) is a chronic neurological disease characterized by demyelination associated with infiltrating white blood cells in the central nervous system (CNS). Nitric oxide synthases (NOS) are a family of enzymes that control the production of nitric oxide. It is possible that neuronal NOS could be involved in MS pathophysiology and hence the nNOS gene is a potential candidate for involvement in disease susceptibility. The aim of this study was to determine whether allelic variation at the nNOS gene locus is associated with MS in an Australian cohort. DNA samples obtained from a Caucasian Australian population affected with MS …