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Identification Of Genes Responsible For Maintenance Of Differentiation Capability In Dental Pulp Stem Cells, Michael B. Flanagan
Identification Of Genes Responsible For Maintenance Of Differentiation Capability In Dental Pulp Stem Cells, Michael B. Flanagan
LSU Doctoral Dissertations
Stem cells exist in various tissues, including dental follicles and dental pulps. Adult stem cells (ASC) can be isolated from patients for autologous transplantation, which eliminates the risk of immune rejection with low or no tumorigenesis. However, one of the challenges is that ASC progressively lose their differentiation ability when cultured in vitro. This prevents expansion of large quantities of high-potential stem cells for therapeutics, especially for stem cells with limited tissue source, such as dental pulp stem cells (DPSC). The goal of this study is to define possible molecular regulation causing loss of differentiation. To achieve this goal, we …