Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Airway hyperresponsiveness (1)
- Alcohol (1)
- Animal model (1)
- Arbovirus (1)
- Asthma (1)
-
- B. burgdorferi (1)
- Borrelia bissettii (1)
- Borrelia burgdorferi (1)
- CXCL1 (1)
- Cecal ligation and puncture (1)
- Craniofacial Defects (1)
- Cytokines (1)
- Dental Follicle Stem Cell (1)
- Dentin Matrix Protein 1 (1)
- Elevated plus-maze (1)
- Emotional understanding (1)
- Envelopment and Egress (1)
- Facilitator (1)
- GGR (1)
- GK (1)
- Gastrointestinal Nematodes (1)
- Gene expression analysis (1)
- HSV (1)
- Haemonchus (1)
- Herpes (1)
- Herpes Virus (1)
- Homoeostasis (1)
- Immune Response (1)
- Immunology (1)
- In utero (1)
Articles 1 - 12 of 12
Full-Text Articles in Entire DC Network
Transcription Coupled Dna Repair In Saccharomyces Cerevisiae: The Interplay Of Facilitators And Repressors, Wentao Li
LSU Doctoral Dissertations
Nucleotide excision repair (NER) is a multi-step cellular process that removes bulky and/or helix-distorting DNA lesions, such as UV induced cyclobutane pyrimidine dimers (CPDs) and bulky chemical adducts. Transcription coupled repair (TCR) is a subpathway of NER dedicated to rapid removal of lesions in the transcribed strand of actively transcribed genes. The TCR mechanism in bacteria has been relatively well elucidated. However, TCR in eukaryotic cells appears to be extremely complicated. The exact nature of the TCR signal and the mechanism of the transcription-repair coupling have been long-standing enigmas. This dissertation focused on how the TCR repressors and facilitators interplay …
Pragmatics, Prosody, And Social Skills Of School-Age Children With Language-Learning Differences, Janet Lynn Bradshaw
Pragmatics, Prosody, And Social Skills Of School-Age Children With Language-Learning Differences, Janet Lynn Bradshaw
LSU Doctoral Dissertations
Social skills are an important aspect of child development that continues to have influences in adolescence and adulthood (Hart, Olsen, Robinson, & Mandleco, 1997). Interacting in a social world requires an integration of many abilities that include social skills and emotional understanding of oneself and other persons. Children who have difficulties with interpreting social cues (e.g., identifying basic emotions and responding to cues in speech) have immediate and progressive consequences in both academics and social living. Children with typical language skills are successfully interacting with peers and acknowledging social rules for different environments (e.g., playing at school vs. playing at …
Genetics And Functions Of Herpes Simplex Virus Type-1 Membrane Proteins Ul20/Gk In Virion Envelopment And Entry, Anu Susan Charles
Genetics And Functions Of Herpes Simplex Virus Type-1 Membrane Proteins Ul20/Gk In Virion Envelopment And Entry, Anu Susan Charles
LSU Doctoral Dissertations
The envelopment and egress of the Herpes Simplex Virus is an important event in the life cycle of the virus. The important membrane proteins required for the envelopment and egress of the virus are glycoproteins gM, gK, gE and non-glycosylated membrane proteins UL20p and UL11. Among them one of the most critical protein is the UL20 protein which has four transmembrane domains with amino and carboxyl termini are predicted to lie within the cytoplasmic side of cellular membranes. Studies done in our laboratory have shown that deletion of UL20 or other lethal mutations have an adverse effect on envelopment and …
In Utero Exposure To Second-Hand Smoke Aggravates Adult Responses To Inhaled Irritants, Rui Xiao
In Utero Exposure To Second-Hand Smoke Aggravates Adult Responses To Inhaled Irritants, Rui Xiao
LSU Doctoral Dissertations
In utero exposure to second-hand smoke (SHS) has modulatory effects on adult lung responses to various irritants. To further elucidate diverse responses with different inhaled irritants and to understand how long the effects persist, we have focused on two environmentally-relevant and asthma-associated irritants--SHS and ovalbumin (OVA)--for adult mice that had been exposed in utero to SHS. We hypothesized that in utero SHS exposure aggravates lung responses to various inhaled irritants, including SHS and OVA, in adult mice beyond the age of 15 weeks; and that the responses will likely exhibit a sex bias. Pregnant BALB/c mice were exposed (days 6-19 …
The Role Of Viral Glycoproteins And Tegument Proteins In Herpes Simplex Virus Type 1 Cytoplasmic Virion Envelopment, Dmitry Vladimirovich Chouljenko
The Role Of Viral Glycoproteins And Tegument Proteins In Herpes Simplex Virus Type 1 Cytoplasmic Virion Envelopment, Dmitry Vladimirovich Chouljenko
LSU Doctoral Dissertations
Herpes simplex virus type 1 (HSV-1) is a ubiquitous neurotropic alphaherpesvirus transmitted by contact with mucocutaneous surfaces of infected individuals. HSV-1 enters the host by fusion of the viral envelope with the host cell plasma membrane, followed by translocation of the viral capsids to the nucleus where viral DNA is injected into the host cell nucleus to initiate viral replication. To generate infectious virions, newly assembled capsids travel to the cytoplasm and undergo a process called secondary envelopment by budding into cytoplasmic vesicles derived from the trans-Golgi network. Cytoplasmic envelopment is a complex process involving interactions between a multitude of …
The Roles Of Inflammation, Oxidative Stress, And Neurotransmitters In An Animal Model Of Post-Traumatic Stress Disorder, Carl Brad Wilson
The Roles Of Inflammation, Oxidative Stress, And Neurotransmitters In An Animal Model Of Post-Traumatic Stress Disorder, Carl Brad Wilson
LSU Doctoral Dissertations
Post-traumatic stress disorder (PTSD), a trauma- and stressor-related disorder, is a condition that can develop in response to life-threatening situations. According to the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM-5), a diagnosis of PTSD necessitates exposure to a life-threatening event, intrusive recollections, avoidance of associated stimuli, hyperarousal, and a significant social impairment. All of these symptoms must persist for at least 30 days and not be due to illness, medication, or substance abuse. To date, no definitive diagnostic biomarkers have been identified for PTSD. Recent research, however, points toward physiological abnormalities in the brain, hypothalamic-pituitary-adrenal (HPA) axis, and …
Influence Of Aedes Aegypti Saliva On The Vertebrate Host Response To Dengue Virus, Michael Kevin Mccracken
Influence Of Aedes Aegypti Saliva On The Vertebrate Host Response To Dengue Virus, Michael Kevin Mccracken
LSU Doctoral Dissertations
Dengue virus (DENV) is maintained in a primarily anthroponotic cycle between humans and the mosquito, Aedes aegypti. Investigations into DENV infection of the vertebrate host generally do not account for the contribution of vector saliva, an inherent part of the mosquito-borne viral inoculum. Feeding by mosquitoes on vertebrate hosts is initiated by probing, which results in physical damage to the skin and vasculature, and the simultaneous introduction of DENV and saliva into the skin. Saliva contains many individual proteins with the potential to modulate host hemostasis and immune responses, thereby facilitating blood feeding and virus transmission. As exogenous antigens, both …
North American Lyme Borreliae: New Distributions And An Insight Into Borrelia Bissettii Infection, Immune Response And Transmission In A Murine Model, Brian Francis Leydet Jr
North American Lyme Borreliae: New Distributions And An Insight Into Borrelia Bissettii Infection, Immune Response And Transmission In A Murine Model, Brian Francis Leydet Jr
LSU Doctoral Dissertations
Lyme borreliosis is an emergent threat to human health. It is estimated that 300,000 cases of Lyme disease are diagnosed annually in the United States. In recent years, non-traditional areas are starting to report more and more cases. While much research has gone into the tick and bacteria responsible for the disease, frequently new Borrelia species are being described and implicated in human illness. These species often go unstudied, and their threat to human health is not known. In the hopes of closing knowledge gaps on Lyme borreliosis in the US, we surveyed a non-endemic state, Louisiana, for Lyme Borrelia …
Outer Surface Lipoprotein Layer Homeostasis And Gene Regulation In Borrelia Burgdorferi, Poonam Dadhwal
Outer Surface Lipoprotein Layer Homeostasis And Gene Regulation In Borrelia Burgdorferi, Poonam Dadhwal
LSU Doctoral Dissertations
The outer surface lipoprotein (osp) layer forms an interface between the internal and the external environment of the Lyme disease spirochete, Borrelia burgdorferi. The homeostatic maintenance of the osp layer effectuates adaptation of B. burgdorferi as it gets transmitted from the tick vector to a mammalian host and vice-versa. However, the regulation of the outer surface lipoproteins (osps) is still a conundrum for borrelia scientists. Part of this dissertation inquires about the homeostatic maintenance of the osp layer. We found that the deletion of the dominantly expressed tick phase osp, OspA, induces expression of two other osps. OspD, and BBJ41. …
Mechanisms Of Innate Immunity In Polymicrobial Sepsis, Liliang Jin
Mechanisms Of Innate Immunity In Polymicrobial Sepsis, Liliang Jin
LSU Doctoral Dissertations
Severe bacterial sepsis leads to a pro-inflammatory condition that can manifest as septic shock, multiple organ failure, and death. Neutrophils are critical for the rapid elimination of bacteria, however, the role of neutrophil chemoattractant CXCL1, pattern recognition receptors (PRRs)- NLR protein 3 (NLRP3) and alcohol in bacterial clearance during sepsis remains elusive. We demonstrate that CXCL1 plays a pivotal role in mediating host defense to polymicrobial sepsis following cecal ligation and puncture (CLP) in gene-deficient mice. CXCL1 appears to be essential for restricting bacterial outgrowth and preventing multiple organ failure and death in mice. Moreover, CXCL1 is essential for neutrophil …
Characteristics Of Dental Follicle Stem Cells And Their Potential Application For Treatment Of Craniofacial Defects, Maryam Rezai Rad
Characteristics Of Dental Follicle Stem Cells And Their Potential Application For Treatment Of Craniofacial Defects, Maryam Rezai Rad
LSU Doctoral Dissertations
Utilization of patient-specific stem cells in regenerative medicine provides a novel treatment approach for diseases and disorders. Embryonic stem cells and induced pluripotent stem cells can differentiate into any cells found within the body; however, ethical, technical and safety concerns have to be overcome before they can be used in clinics. Patient-specific stem cells can be isolated from adult tissues with no ethical, fewer technical, and safety concerns. Obtaining tissues for stem cell isolation usually requires invasive procedures, but impacted teeth are often extracted in the clinics and can be used for isolation of dental follicle stem cells (DFSCs). The …
Comparison Of Immune Responses During Gastrointestinal Helminth Self-Cure Expulsion Between Resistant Gulf Coast Native And Susceptible Suffolk Sheep, Javier Jesus Garza
Comparison Of Immune Responses During Gastrointestinal Helminth Self-Cure Expulsion Between Resistant Gulf Coast Native And Susceptible Suffolk Sheep, Javier Jesus Garza
LSU Doctoral Dissertations
The immune response to the self-cure phenomenon seen during gastrointestinal nematode (GIN) parasitism of small ruminants was compared between sheep breeds that are resistant or susceptible to Haemonchus contortus infection. Fifty-four Gulf Coast Native (resistant) and Suffolk (susceptible) lambs were allowed to acquire a natural GIN infection on pasture and were then randomly allocated into 4 groups. After being moved to parasite free housing for 2 months, lambs were given a challenge infection of 20,000 H. contortus L3. Fecal egg counts (FEC) were monitored throughout the study and animals were necropsied at 0, 1, 3, and 7 days post infection …