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Nanostructures, Concentrations And Energies: An Ideal Equation To Extend Therapeutic Efficiency On Radioresistant 9l Tumour Cells Using Ta2o5 Ceramic Nanostructured Particles, Ryan Brown, Stephanie Corde, Sianne Oktaria, Konstantin K. Konstantinov, Anatoly B. Rosenfeld, Michael L. F Lerch, Moeava Tehei

Illawarra Health and Medical Research Institute

This work presents an in-depth analysis into the dependencies of radiosensitisation on X-ray beam energy, particle morphology and particle concentration for Ta₂O₅ nanostructured particles. A maximum sensitisation enhancement ratio of 1.46 was attained with irradiation of a 10 MV x-ray photon beam on 9L cells exposed to the less aggregated form of NSPs at 500 μg/mL^-1. A significant increase in sensitisation of 30% was noted at 150 kVp for irradiation of the less aggregated form of tantalum pentoxide NSPs compared to its more agglomerated counterpart. Interestingly, no differences in sensitisation were observed between 50 and …