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The Key Regulatory Roles Of The Pi3k/Akt Signaling Pathway In The Functionalities Of Mesenchymal Stem Cells And Applications In Tissue Regeneration, Jiezhong Chen, Ross Crawford, Chen Chen, Yin Xiao
The Key Regulatory Roles Of The Pi3k/Akt Signaling Pathway In The Functionalities Of Mesenchymal Stem Cells And Applications In Tissue Regeneration, Jiezhong Chen, Ross Crawford, Chen Chen, Yin Xiao
Illawarra Health and Medical Research Institute
Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into various cell types and have been widely used in tissue engineering application. In tissue engineering, a scaffold, MSCs and growth factors are used as essential components and their interactions have been regarded to be important for regeneration of tissues. A critical problem for MSCs in tissue engineering is their low survival ability and functionality. Most MSCs are going to be apoptotic after transplantation. Therefore, increasing MSC survival ability and functionalities is the key for potential applications of MSCs. Several approaches have been studied to increase MSC tissue forming capacity …
Applications Of Nanotechnology For Melanoma Treatment, Diagnosis, And Theranostics, Jiezhong Chen, Renfu Shao, Xu Dong Zhang, Chen Chen
Applications Of Nanotechnology For Melanoma Treatment, Diagnosis, And Theranostics, Jiezhong Chen, Renfu Shao, Xu Dong Zhang, Chen Chen
Illawarra Health and Medical Research Institute
Melanoma is the most aggressive type of skin cancer and has very high rates of mortality. An early stage melanoma can be surgically removed, with a survival rate of 99%. However, metastasized melanoma is difficult to cure. The 5-year survival rates for patients with metastasized melanoma are still below 20%. Metastasized melanoma is currently treated by chemotherapy, targeted therapy, immunotherapy and radiotherapy. The outcome of most of the current therapies is far from optimistic. Although melanoma patients with a mutation in the oncogene v-Raf murine sarcoma viral oncogene homolog B1 (BRAF) have an initially higher positive response rate to targeted …