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Cellular Senescence In Progenitor Cells Contributes To Diminished Remyelination Potential In Progressive Multiple Sclerosis., Alexandra M Nicaise, Laura J Wagstaff, Cory M Willis, Carolyn Paisie, Harshpreet Chandok, Paul Robson, Valentina Fossati, Anna Williams, Stephen J Crocker
Cellular Senescence In Progenitor Cells Contributes To Diminished Remyelination Potential In Progressive Multiple Sclerosis., Alexandra M Nicaise, Laura J Wagstaff, Cory M Willis, Carolyn Paisie, Harshpreet Chandok, Paul Robson, Valentina Fossati, Anna Williams, Stephen J Crocker
Faculty Research 2019
Cellular senescence is a form of adaptive cellular physiology associated with aging. Cellular senescence causes a proinflammatory cellular phenotype that impairs tissue regeneration, has been linked to stress, and is implicated in several human neurodegenerative diseases. We had previously determined that neural progenitor cells (NPCs) derived from induced pluripotent stem cell (iPSC) lines from patients with primary progressive multiple sclerosis (PPMS) failed to promote oligodendrocyte progenitor cell (OPC) maturation, whereas NPCs from age-matched control cell lines did so efficiently. Herein, we report that expression of hallmarks of cellular senescence were identified in SOX2+ progenitor cells within white matter lesions …